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Reflections on the theory of "silver bullet" octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and…

Overview of attention for article published in EJNMMI Research, January 2011
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1 tweeter

Citations

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20 Mendeley
Title
Reflections on the theory of "silver bullet" octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysis.
Published in
EJNMMI Research, January 2011
DOI 10.1186/2191-219x-1-9
Pubmed ID
Abstract

The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on this review. The central issue of this paper will be the use of somatostatin analogs, i.e., octreotide, in clinical imaging procedures as well as in relation to neuroendocirne tumors. Newly described characteristics of G-protein coupled receptors such as the formation of receptor mosaics will be discussed. A small section will enumerate the regulatory processes found in the cell membrane. Possible new interpretations, other than tumor detection, based on imaging procedures with somatostatin analogs will be presented. The readers will be taken to situations such as inflammation, nociception, mechanosensing, chemosensing, fibrosis, taste, and vascularity where somatostatin is involved. Thyroid-associated orbitopathy will be used as a model for the development of multi-agent therapeutics. The final graphical summary depicts the multifactorial properties of ligand binding.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 2 10%
Unknown 18 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 30%
Professor 3 15%
Researcher 3 15%
Student > Doctoral Student 2 10%
Other 1 5%
Other 3 15%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 8 40%
Agricultural and Biological Sciences 3 15%
Chemistry 2 10%
Physics and Astronomy 2 10%
Immunology and Microbiology 1 5%
Other 2 10%
Unknown 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2012.
All research outputs
#2,901,758
of 3,628,883 outputs
Outputs from EJNMMI Research
#29
of 82 outputs
Outputs of similar age
#166,563
of 231,276 outputs
Outputs of similar age from EJNMMI Research
#2
of 3 outputs
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So far Altmetric has tracked 82 research outputs from this source. They receive a mean Attention Score of 0.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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