The authors of "In vivo genome and base editing of a human PCSK9 k…" (https://t.co/UgiMcAIwi7) included RRIDs in their paper! Thank you for making your #methodsmatter. #accelerateopenscience
@DakotaQ11 @sbarnettARK @VerveTx has really interesting pre-clinical data in non-human primates on in vivo editing PCSK9 to lower LDL. https://t.co/hGqgfUc1QE This is a nice demonstration of in vivo base editing of PCSK9 in mouse models: https://t.co/NM
RT @BMCBiology: In case you missed it: In vivo #genome and base #editing of a human #PCSK9 knock-in hypercholesterolemic mouse model A kno…
In case you missed it: In vivo #genome and base #editing of a human #PCSK9 knock-in hypercholesterolemic mouse model A knock-out read from Marcello Maresca and colleagues at @AstraZeneca. Find out more here: https://t.co/Chtm2ewbLF https://t.co/NV49EbZO2P
Marcello Maresca and colleagues @AstraZeneca use #baseediting to create a humanized #MouseModel of #hypercholesterolemia which can be used to evaluate #antibody and #GeneEditing-based #therapies. #CRISPR #PCSK9 - https://t.co/eoHkn4K7fb https://t.co/Mi83nm
RT @SteveRees16: Great publication from the genome editing team @AstraZeneca describing the use of base editing to create mouse models of h…
RT @BMCBiology: Marcello Maresca and colleagues @AstraZeneca describe a humanized #MouseModel with liver-specific expression of #human #PCS…
Great publication from the genome editing team @AstraZeneca describing the use of base editing to create mouse models of hypercholesterolemia. Great potential to validate new targets, create disease models and as a medicine in it’s own right #CRISPR htt
Marcello Maresca and colleagues @AstraZeneca describe a humanized #MouseModel with liver-specific expression of #human #PCSK9 and a #hypercholesterolemia #phenotype, showing that it can be used to evaluate #antibody and #GeneEditing-based #therapies. - htt
In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model https://t.co/wP7AY3Dzk1