Title |
Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
|
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Published in |
Diabetologia, May 2008
|
DOI | 10.1007/s00125-008-1018-8 |
Pubmed ID | |
Authors |
T. Rönn, P. Poulsen, O. Hansson, J. Holmkvist, P. Almgren, P. Nilsson, T. Tuomi, B. Isomaa, L. Groop, A. Vaag, C. Ling |
Abstract |
Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-genetic factors influence a component of the respiratory chain, COX7A1, previously shown to be downregulated in skeletal muscle from patients with type 2 diabetes. The specific aims were to: (1) evaluate the impact of genetic (single nucleotide polymorphisms [SNPs]), epigenetic (DNA methylation) and non-genetic (age) factors on the expression of COX7A1 in human skeletal muscle; and (2) investigate whether common variants in the COX7A1 gene are associated with increased risk of type 2 diabetes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 2 | 2% |
Korea, Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
India | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
Unknown | 117 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 20% |
Researcher | 23 | 19% |
Professor > Associate Professor | 15 | 12% |
Student > Master | 15 | 12% |
Student > Doctoral Student | 7 | 6% |
Other | 22 | 18% |
Unknown | 17 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 36 | 29% |
Biochemistry, Genetics and Molecular Biology | 30 | 24% |
Medicine and Dentistry | 23 | 19% |
Sports and Recreations | 4 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 10 | 8% |
Unknown | 19 | 15% |