Title |
Induction of apoptosis, stimulation of cell-cycle arrest and inhibition of angiogenesis make human amnion-derived cells promising sources for cell therapy of cancer
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Published in |
Cell and Tissue Research, February 2016
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DOI | 10.1007/s00441-016-2364-3 |
Pubmed ID | |
Authors |
Hassan Niknejad, Ghasem Yazdanpanah, Abolhassan Ahmadiani |
Abstract |
Amniotic membrane (AM), the nearest layer of fetal membranes to the fetus, contains two types of cells with unique characteristics that make them excellent candidates for clinical applications. Amniotic epithelial and mesenchymal cells have low immunogenicity, anti-inflammation, anti-fibrosis and anti-bacterial properties and no ethical issues. Although amniotic cells have stem cell properties and express transcription factors specific for pluripotent stem cells, they are not tumorigenic after transplantation. In the last decade, a new line of research has been initiated with a focus on the anti-proliferative effects of amniotic epithelial and mesenchymal cells on tumor growth. Amnion-derived epithelial and mesenchymal cells inhibit tumor growth and invasion through three pathways: the induction of apoptosis, the stimulation of cell-cycle arrest and the inhibition of angiogenesis. In this review, the various aspects of the anti-cancer properties of amnion-derived cells and the underlying mechanisms are discussed with emphasis on the translation of the cell therapy of cancer from experimental into clinical practice. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 2 | 6% |
Colombia | 1 | 3% |
Unknown | 33 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 14% |
Student > Master | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Professor > Associate Professor | 4 | 11% |
Other | 8 | 22% |
Unknown | 6 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 28% |
Agricultural and Biological Sciences | 6 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Engineering | 2 | 6% |
Social Sciences | 1 | 3% |
Other | 3 | 8% |
Unknown | 11 | 31% |