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‘Chronomics’ in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill

Overview of attention for article published in Intensive Care Medicine Experimental, May 2014
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Title
‘Chronomics’ in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill
Published in
Intensive Care Medicine Experimental, May 2014
DOI 10.1186/2197-425x-2-18
Pubmed ID
Authors

Vasilios Papaioannou, Alexandre Mebazaa, Benoît Plaud, Matthieu Legrand

Abstract

Complex interrelations exist between the master central clock, located in the suprachiasmatic nuclei of the hypothalamus, and several peripheral clocks, such as those found in different immune cells of the body. Moreover, external factors that are called 'timekeepers', such as light/dark and sleep/wake cycles, interact with internal clocks by synchronizing their different oscillation phases. Chronobiology is the science that studies biologic rhythms exhibiting recurrent cyclic behavior. Circadian rhythms have a duration of approximately 24 h and can be assessed through chronobiologic analysis of time series of melatonin, cortisol, and temperature. Critically ill patients experience severe circadian deregulation due to not only the lack of effective timekeepers in the intensive care unit (ICU) environment but also systemic inflammation. The latter has been found in both animal and human studies to disrupt circadian rhythmicity of all measured biomarkers. The aims of this article are to describe circadian physiology during acute stress and to discuss the effects of ICU milieu upon circadian rhythms, in order to emphasize the value of considering circadian-immune disturbance as a potential tool for personalized treatment. Thus, besides neoplastic processes, critical illness could be linked to what has been referred as 'chronomics': timing and rhythm. In addition, different therapeutic perspectives will be presented in association with environmental approaches that could restore circadian connection and hasten physical recovery.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Unknown 66 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 16%
Student > Ph. D. Student 10 15%
Student > Bachelor 7 10%
Professor > Associate Professor 6 9%
Student > Master 6 9%
Other 13 19%
Unknown 14 21%
Readers by discipline Count As %
Medicine and Dentistry 23 34%
Agricultural and Biological Sciences 9 13%
Nursing and Health Professions 8 12%
Biochemistry, Genetics and Molecular Biology 2 3%
Psychology 1 1%
Other 3 4%
Unknown 21 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2016.
All research outputs
#20,303,950
of 22,842,950 outputs
Outputs from Intensive Care Medicine Experimental
#364
of 447 outputs
Outputs of similar age
#193,104
of 227,350 outputs
Outputs of similar age from Intensive Care Medicine Experimental
#2
of 5 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 447 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,350 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.