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The multiple roles of sucrase-isomaltase in the intestinal physiology

Overview of attention for article published in Molecular and Cellular Pediatrics, January 2016
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Average Attention Score compared to outputs of the same age and source

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2 X users
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1 Wikipedia page
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1 Google+ user

Citations

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80 Mendeley
Title
The multiple roles of sucrase-isomaltase in the intestinal physiology
Published in
Molecular and Cellular Pediatrics, January 2016
DOI 10.1186/s40348-016-0033-y
Pubmed ID
Authors

Birthe Gericke, Mahdi Amiri, Hassan Y. Naim

Abstract

Osmotic diarrhea and abdominal pain in humans are oftentimes associated with carbohydrate malabsorption in the small intestine due to loss of function of microvillar disaccharidases. Disaccharidases are crucial for the digestion and the subsequent absorption of carbohydrates. This review focuses on sucrase-isomaltase as the most abundant intestinal disaccharidase and the primary or induced pathological conditions that affect its physiological function. Congenital defects are primary factors which directly influence the transport and function of sucrase-isomaltase in a healthy epithelium. Based on the mutation type and the pattern of inheritance, a mutation in the sucrase-isomaltase gene may exert a variety of symptoms ranging from mild to severe. However, structure and function of wild type sucrase-isomaltase can be also affected by secondary factors which influence its structure and function either specifically via certain inhibitors and therapeutic agents or generally as a part of intestinal pathogenesis, for example in the inflammatory responses. Diagnosis of sucrase-isomaltase deficiency and discriminating it from other gastrointestinal intolerances can be latent in the patients because of common symptoms observed in all of these cases.Here, we summarize the disorders that implicate the digestive function of sucrase-isomaltase as well as the diagnostic and therapeutic strategies utilized to restore normal intestinal function.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 20%
Student > Master 13 16%
Student > Bachelor 12 15%
Researcher 8 10%
Student > Doctoral Student 6 8%
Other 9 11%
Unknown 16 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 28%
Agricultural and Biological Sciences 15 19%
Medicine and Dentistry 9 11%
Chemistry 5 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 7 9%
Unknown 18 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2020.
All research outputs
#6,156,892
of 22,842,950 outputs
Outputs from Molecular and Cellular Pediatrics
#19
of 98 outputs
Outputs of similar age
#100,636
of 396,750 outputs
Outputs of similar age from Molecular and Cellular Pediatrics
#5
of 10 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 98 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,750 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.