Title |
SET7/9 inhibits oncogenic activities through regulation of Gli-1 expression in breast cancer
|
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Published in |
Tumor Biology, January 2016
|
DOI | 10.1007/s13277-016-4822-7 |
Pubmed ID | |
Authors |
Yongchun Song, Jianli Zhang, Tao Tian, Xiao Fu, Wenjuan Wang, Suoni Li, Tingting Shi, Aili Suo, Zhiping Ruan, Hui Guo, Yu Yao |
Abstract |
SET7/9 is a protein lysine methyltransferase that had been initially identified as a histone lysine methyltransferase which generates monomethylation at histone 3 lysine 4. Different functions were attributed to the protein methylation mediated by SET7/9. In this study, we found that the expression of SET7/9 declined in a majority of the human breast cancer tissues examined compared with normal tissues. Knockdown of SET7/9 promoted the proliferation, migration, and invasion of breast cancer cells. Knockdown of SET7/9 also increased the tumorigenicity of breast cancer cells in vivo. On the contrary, overexpression of SET7/9 in breast cancer cells inhibited these processes. Microarray analysis indicated that Gli-1 may play function as a downstream factor of SET7/9. Overexpression of SET7/9SET7/9 inhibits Gli-1 expression. While knockdown of SET7/9 promotes the expression of Gli-1. Gli-1 inhibited by cyclopamine blocked knockdown SET7/9-driven proliferation, migration, and invasion in breast cancer cell. Furthermore, Gli-1 expression in human breast cancer tissues is negatively correlated with SET7/9 expression. Together, these results helped to realize the antioncogene functions of SET7/9 in breast cancer cells and provided a novel direction to treat breast cancer. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 18 | 100% |
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Student > Master | 4 | 22% |
Student > Ph. D. Student | 3 | 17% |
Student > Bachelor | 2 | 11% |
Student > Doctoral Student | 1 | 6% |
Unspecified | 1 | 6% |
Other | 2 | 11% |
Unknown | 5 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 28% |
Biochemistry, Genetics and Molecular Biology | 5 | 28% |
Unspecified | 1 | 6% |
Chemistry | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Other | 0 | 0% |
Unknown | 5 | 28% |