↓ Skip to main content

Microglial activation in stroke: Therapeutic targets

Overview of attention for article published in Neurotherapeutics, October 2010
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
3 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
201 Dimensions

Readers on

mendeley
117 Mendeley
Title
Microglial activation in stroke: Therapeutic targets
Published in
Neurotherapeutics, October 2010
DOI 10.1016/j.nurt.2010.07.005
Pubmed ID
Authors

Midori A. Yenari, Tiina M. Kauppinen, Raymond A. Swanson

Abstract

Microglial activation is an early response to brain ischemia and many other stressors. Microglia continuously monitor and respond to changes in brain homeostasis and to specific signaling molecules expressed or released by neighboring cells. These signaling molecules, including ATP, glutamate, cytokines, prostaglandins, zinc, reactive oxygen species, and HSP60, may induce microglial proliferation and migration to the sites of injury. They also induce a nonspecific innate immune response that may exacerbate acute ischemic injury. This innate immune response includes release of reactive oxygen species, cytokines, and proteases. Microglial activation requires hours to days to fully develop, and thus presents a target for therapeutic intervention with a much longer window of opportunity than acute neuroprotection. Effective agents are now available for blocking both microglial receptor activation and the microglia effector responses that drive the inflammatory response after stroke. Effective agents are also available for targeting the signal transduction mechanisms linking these events. However, the innate immune response can have beneficial as well deleterious effects on outcome after stoke, and a challenge will be to find ways to selectively suppress the deleterious effects of microglial activation after stroke without compromising neurovascular repair and remodeling.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
France 1 <1%
Canada 1 <1%
Unknown 113 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 21%
Researcher 21 18%
Student > Master 16 14%
Student > Doctoral Student 15 13%
Student > Bachelor 13 11%
Other 27 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 29%
Medicine and Dentistry 28 24%
Neuroscience 25 21%
Unspecified 11 9%
Biochemistry, Genetics and Molecular Biology 9 8%
Other 10 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2012.
All research outputs
#6,851,507
of 13,044,919 outputs
Outputs from Neurotherapeutics
#345
of 575 outputs
Outputs of similar age
#87,386
of 209,773 outputs
Outputs of similar age from Neurotherapeutics
#2
of 8 outputs
Altmetric has tracked 13,044,919 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 575 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,773 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.