The negative effect of unloading exceeds the bone-sparing effect of alkaline supplementation: a bed rest study

Potassium bicarbonate was administrated to an already alkaline diet in seven male subjects during a 21-day bed rest study and was able to decrease bed rest induced increased calcium excretion but failed to prevent bed rest-induced bone resorption. https://

The more alkaline status, achieved by daily 90 mmol KHCO3 , reduced renal calcium excretion during bed rest but was not able to prevent immobilization-induced bone resorption. Bed rest study in 7 males Frings-Meuthen P et al. Osteoporos Int 25 Sept 2018 h