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The effect of olive oil-based ketogenic diet on serum lipid levels in epileptic children

Overview of attention for article published in Neurological Sciences, December 2015
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Title
The effect of olive oil-based ketogenic diet on serum lipid levels in epileptic children
Published in
Neurological Sciences, December 2015
DOI 10.1007/s10072-015-2436-2
Pubmed ID
Authors

Orkide Güzel, Unsal Yılmaz, Utku Uysal, Nur Arslan

Abstract

Ketogenic diet (KD) is one of the most effective therapies for intractable epilepsy. Olive oil is rich in monounsaturated fatty acids and antioxidant molecules and has some beneficial effects on lipid profile, inflammation and oxidant status. The aim of this study was to evaluate the serum lipid levels of children who were receiving olive oil-based KD for intractable seizures at least 1 year. 121 patients (mean age 7.45 ± 4.21 years, 57 girls) were enrolled. At baseline and post-treatment 1, 3, 6, and 12 months body mass index-SDS, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglyceride levels were measured. Repeated measure ANOVA with post hoc Bonferroni correction was used for data analysis. The mean duration of KD was 15.4 ± 4.1 months. Mean total cholesterol, LDL-cholesterol and triglyceride levels were significantly higher at 1st, 3rd, 6th and 12th months of the KD treatment, compared to pre-treatment levels (p = 0.001), but showed no difference among during-treatment measurements. Mean body mass index-SDS and HDL-cholesterol levels were not different among the baseline and follow-up time points (p = 0.113 and p = 0.067, respectively). No child in this study discontinued the KD because of dyslipidemia. Even if rich in olive oil, high-fat KD causes significant increase in LDL-cholesterol and triglyceride levels. More studies are needed to determine the effect of KD on serum lipids in children using different fat sources in the diet.

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Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Student > Bachelor 10 15%
Researcher 6 9%
Other 4 6%
Student > Doctoral Student 4 6%
Other 15 23%
Unknown 14 21%
Readers by discipline Count As %
Medicine and Dentistry 12 18%
Nursing and Health Professions 10 15%
Biochemistry, Genetics and Molecular Biology 5 8%
Agricultural and Biological Sciences 4 6%
Psychology 3 5%
Other 13 20%
Unknown 19 29%