@nigelj08223325 @A_MacLullich @drpeterlange @willchegwidden @ZoeTieges @DrKarinNeufeld @dr_shibley @JimRudolphMD @deliriumkrish @WesElyMD Absolutely. The chronotherapy literature on this is fascinating as well: https://t.co/zS96USTsnw https://t.co/Py6wXC
“However, inconsistencies between studies suggest a need for more prospective randomized controlled trials with sufficient statistical power.” https://t.co/IG97K87QOV
“Here, we summarize major findings from recent research in this area (2013–2017). In general, nighttime administration of antihypertensives improved overall 24-h blood pressure profiles regardless of disease comorbidity.“ https://t.co/IG97K87QOV
“To more effectively reduce nocturnal blood pressure and still counteract the morning surge in blood pressure, a number of studies have examined moving one or more antihypertensives from morning to bedtime dosing.” https://t.co/IG97K87QOV
“Historically, antihypertensive therapy involves morning doses, usually aimed at reducing daytime blood pressure surges, but an absence of nocturnal dipping blood pressure is also associated with increased cardiovascular risk.” https://t.co/IG97K87QOV
“There is a well-documented 24-h pattern of blood pressure with a morning surge that may contribute to the observed morning increase in adverse cardiovascular events.“ https://t.co/IG97K87QOV
“This suggests that chronotherapy, either in terms of external clock time or internal biological time, is underutilized and could be a major consideration to improve modern personalized medicine.” https://t.co/IG97K87QOV
“Recent examination of 12 different organs in a mouse model demonstrates that the protein targets of 56% of the top-selling and World Health Organization essential medicines oscillate with circadian profiles.” https://t.co/IG97K87QOV
“Since it is difficult to instantaneously assess circadian phase, there are virtually no medications currently administered based on internal biological time.” https://t.co/IG97K87QOV
“Moreover, internal biological time (circadian phase) can differ between people in relation to external clock time.” https://t.co/IG97K87QOV
“Currently, very few medications are administered based on the time of day in order to optimize beneficial effects or reduce side effects.“ https://t.co/IG97K87QOV
“A medication’s effects are also dependent on receptor site availability and function, which can also be affected by the circadian system and by prior behaviors, such as exercise.” https://t.co/IG97K87QOV
“The sum of these daily circadian (24-h) and behavioral physiological patterns can therefore affect a medication’s bioavailability and duration of action through absorption, distribution, metabolism, and elimination.’ https://t.co/IG97K87QOV
The daily patterns of behaviors “influence the daily fluctuations of gastric pH, gastric emptying, gastrointestinal transit time, organ blood flow, liver enzyme activity, and renal function.” https://t.co/IG97K87QOV
“The daily patterns of behaviors, including the sleep-wake, rest-activity, and fasting-feeding cycles, influence the daily fluctuations of (body activities).” https://t.co/IG97K87QOV
高血圧とChronotherapy https://t.co/DEePTva69y
#CircadianMedicine - New frontier for treating hypertension. Great new review paper by Dr. Steven Shea's group. https://t.co/RGN4vyJXdL https://t.co/0KK6ZJslkw
Chronotherapy for Hypertension. https://t.co/nCdEUu60DW