Protein–ligand interfaces are polarized: discovery of a strong trend for intermolecular hydrogen bonds to favor donors on the protein side with implications for predicting and designing ligand…

@D_B_McConnell @sky_ferrara Another type of skewing results from atom type distributions in both ligands & proteins. My view is that 'polarization' of protein-ligand interfaces is actually the result of HB donor-acceptor imbalance in ligand structures

Protein-ligand interfaces are polarized: Discovery of a strong trend for intermolecular hydrogen bonds to favor donors on the protein side with implications for predicting and designing ligand complexes published as: https://t.co/69vvwxbG6D @springerpub #b