Title |
Epigenetic influences on genetically triggered thoracic aortic aneurysm
|
---|---|
Published in |
Biophysical Reviews, September 2018
|
DOI | 10.1007/s12551-018-0460-1 |
Pubmed ID | |
Authors |
Stefanie S. Portelli, Elizabeth N. Robertson, Cassandra Malecki, Kiersten A. Liddy, Brett D. Hambly, Richmond W. Jeremy |
Abstract |
Genetically triggered thoracic aortic aneurysms (TAAs) account for 30% of all TAAs and can result in early morbidity and mortality in affected individuals. Epigenetic factors are now recognised to influence the phenotype of many genetically triggered conditions and have become an area of interest because of the potential for therapeutic manipulation. Major epigenetic modulators include DNA methylation, histone modification and non-coding RNA. This review examines epigenetic modulators that have been significantly associated with genetically triggered TAAs and their potential utility for translation to clinical practice. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 33% |
Other | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Researcher | 2 | 11% |
Student > Doctoral Student | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 39% |
Biochemistry, Genetics and Molecular Biology | 3 | 17% |
Agricultural and Biological Sciences | 2 | 11% |
Unknown | 6 | 33% |