| Title |
Systemic Treatment with the Enteric Bacterial Fermentation Product, Propionic Acid, Reduces Acoustic Startle Response Magnitude in Rats in a Dose-Dependent Fashion: Contribution to a Rodent Model of ASD
|
|---|---|
| Published in |
Neurotoxicity Research, September 2018
|
| DOI | 10.1007/s12640-018-9960-9 |
| Pubmed ID | |
| Authors |
Corey L. Kamen, Danna L. Zevy, Jordan M. Ward, Indra R. Bishnoi, Martin Kavaliers, Klaus-Peter Ossenkopp |
| Abstract |
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, characterized by cognitive and sensorimotor deficits, among others. Hypo-sensitivity and hyper-sensitivity to different stimuli within the same sensory modality, a prominent symptom of ASD, can be assessed by acoustic startle response (ASR) and prepulse inhibition (PPI). Propionic acid (PPA) is a short-chain fatty acid and a by-product of the human gut microbiome. Rodents treated with PPA has been found to produce ASD-related behavioral abnormalities, gastrointestinal discomfort, and conditioned aversions. The present study examined ASR and PPI in adult male rats treated systemically (intraperitoneal injections) with two different doses of PPA. A single injection of PPA produced significant dose-dependent reductions in startle response magnitude relative to control rats. However, PPA-treated rats did not show significant sensorimotor gating abnormalities relative to controls, based on the PPI measures. These findings add to the growing body of evidence supporting the validity of the PPA rodent model of ASD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 273 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 273 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 3% |
| Researcher | 7 | 3% |
| Student > Ph. D. Student | 7 | 3% |
| Student > Doctoral Student | 4 | 1% |
| Other | 3 | 1% |
| Other | 6 | 2% |
| Unknown | 237 | 87% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 4% |
| Neuroscience | 6 | 2% |
| Psychology | 4 | 1% |
| Agricultural and Biological Sciences | 4 | 1% |
| Nursing and Health Professions | 2 | <1% |
| Other | 7 | 3% |
| Unknown | 239 | 88% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2018.
All research outputs
#18,650,639
of 23,105,443 outputs
Outputs from Neurotoxicity Research
#641
of 889 outputs
Outputs of similar age
#261,615
of 341,808 outputs
Outputs of similar age from Neurotoxicity Research
#12
of 22 outputs
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