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Cardiovascular adverse effects of phenytoin

Overview of attention for article published in Journal of Neurology, December 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

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11 Dimensions

Readers on

mendeley
45 Mendeley
Title
Cardiovascular adverse effects of phenytoin
Published in
Journal of Neurology, December 2015
DOI 10.1007/s00415-015-7967-1
Pubmed ID
Authors

B. Guldiken, J. Rémi, Soheyl Noachtar

Abstract

Phenytoin is an established drug in the treatment of acute repetitive seizures and status epilepticus. One of its main advantages over benzodiazepines is the less sedative effect. However, the possibility of cardiovascular adverse effects with the intravenous use of phenytoin cause a reluctance to its usage, and this has lead to a search for safer anticonvulsant drugs. In this study, we aimed to review the studies which evaluated the safety of phenytoin with respect to cardiovascular adverse effects. The original clinical trials and case reports listed in PUBMED in English language between the years of 1946-2014 were evaluated. As the key words, "phenytoin, diphenylhydantoin, epilepsy, seizure, cardiac toxicity, asystole, arrhythmia, respiratory arrest, hypotension, death" were used. Thirty-two clinical trials and ten case reports were identified. In the case reports, a rapid infusion rate (>50 mg/min) of phenytoin appeared as the major cause of increased mortality. In contrast, no serious cardiovascular adverse effects leading to death were met in the clinical trials which applied the recommended infusion rate and dosages. An infusion rate of 50 mg/min was reported to be safe for young patients. For old patients and patients with a cardiovascular co-morbidity, a slower infusion rate was recommended with a careful follow-up of heart rhythm and blood pressure. No cardiovascular adverse effect was reported in oral phenytoin overdoses except one case with a very high serum phenytoin level and hypoalbuminemia. Phenytoin is an effective and well tolerated drug in the treatment of epilepsy. Intravenous phenytoin is safe when given at recommended infusion rates and doses.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Unspecified 8 18%
Student > Postgraduate 7 16%
Student > Bachelor 7 16%
Researcher 6 13%
Other 5 11%
Other 12 27%
Readers by discipline Count As %
Medicine and Dentistry 20 44%
Unspecified 13 29%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Agricultural and Biological Sciences 3 7%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2019.
All research outputs
#1,974,805
of 13,022,627 outputs
Outputs from Journal of Neurology
#350
of 2,482 outputs
Outputs of similar age
#60,119
of 356,620 outputs
Outputs of similar age from Journal of Neurology
#21
of 58 outputs
Altmetric has tracked 13,022,627 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,482 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 356,620 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.