| Title |
Beta-alanine (Carnosyn™) supplementation in elderly subjects (60–80 years): effects on muscle carnosine content and physical capacity
|
|---|---|
| Published in |
Amino Acids, December 2011
|
| DOI | 10.1007/s00726-011-1190-x |
| Pubmed ID | |
| Authors |
Serena del Favero, Hamilton Roschel, Marina Y. Solis, Ana P. Hayashi, Guilherme G. Artioli, Maria Concepción Otaduy, Fabiana B. Benatti, Roger C. Harris, John A. Wise, Cláudia C. Leite, Rosa M. Pereira, Ana L. de Sá-Pinto, Antonio Herbert Lancha-Junior, Bruno Gualano |
| Abstract |
The aim of this study was to investigate the effects of beta-alanine supplementation on exercise capacity and the muscle carnosine content in elderly subjects. Eighteen healthy elderly subjects (60-80 years, 10 female and 4 male) were randomly assigned to receive either beta-alanine (BA, n=12) or placebo (PL, n=6) for 12 weeks. The BA group received 3.2 g of beta-alanine per day (2×800 mg sustained-release Carnosyn™ tablets, given 2 times per day). The PL group received 2× (2×800 mg) of a matched placebo. At baseline (PRE) and after 12 weeks (POST-12) of supplementation, assessments were made of the muscle carnosine content, anaerobic exercise capacity, muscle function, quality of life, physical activity and food intake. A significant increase in the muscle carnosine content of the gastrocnemius muscle was shown in the BA group (+85.4%) when compared with the PL group (+7.2%) (p=0.004; ES: 1.21). The time-to-exhaustion in the constant-load submaximal test (i.e., TLIM) was significantly improved (p=0.05; ES: 1.71) in the BA group (+36.5%) versus the PL group (+8.6%). Similarly, time-to-exhaustion in the incremental test was also significantly increased (p=0.04; ES 1.03) following beta-alanine supplementation (+12.2%) when compared with placebo (+0.1%). Significant positive correlations were also shown between the relative change in the muscle carnosine content and the relative change in the time-to-exhaustion in the TLIM test (r=0.62; p=0.01) and in the incremental test (r=0.48; p=0.02). In summary, the current data indicate for the first time, that beta-alanine supplementation is effective in increasing the muscle carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 31% |
| Spain | 3 | 19% |
| Chile | 1 | 6% |
| Italy | 1 | 6% |
| United Kingdom | 1 | 6% |
| Unknown | 5 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 75% |
| Practitioners (doctors, other healthcare professionals) | 3 | 19% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 186 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 35 | 19% |
| Student > Bachelor | 30 | 16% |
| Student > Ph. D. Student | 19 | 10% |
| Researcher | 18 | 10% |
| Student > Doctoral Student | 10 | 5% |
| Other | 36 | 19% |
| Unknown | 39 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 44 | 24% |
| Medicine and Dentistry | 32 | 17% |
| Nursing and Health Professions | 21 | 11% |
| Agricultural and Biological Sciences | 19 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 3% |
| Other | 22 | 12% |
| Unknown | 43 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2023.
All research outputs
#1,316,871
of 25,134,448 outputs
Outputs from Amino Acids
#69
of 1,615 outputs
Outputs of similar age
#8,290
of 253,098 outputs
Outputs of similar age from Amino Acids
#3
of 28 outputs
Altmetric has tracked 25,134,448 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,615 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 95% of its peers.
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