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Subfoveal choroidal thickness as a predictor of treatment response to anti-vascular endothelial growth factor therapy for polypoidal choroidal vasculopathy

Overview of attention for article published in Graefe's Archive of Clinical & Experimental Ophthalmology, December 2015
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Title
Subfoveal choroidal thickness as a predictor of treatment response to anti-vascular endothelial growth factor therapy for polypoidal choroidal vasculopathy
Published in
Graefe's Archive of Clinical & Experimental Ophthalmology, December 2015
DOI 10.1007/s00417-015-3221-x
Pubmed ID
Authors

Hyesun Kim, Sung Chul Lee, Kye Yoon Kwon, Ji Hwan Lee, Hyoung Jun Koh, Suk Ho Byeon, Sung Soo Kim, Min Kim, Christopher Seungkyu Lee

Abstract

To investigate whether subfoveal choroidal thickness predicted treatment response to anti-vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV). This retrospective observational case series included 66 eyes of 60 patients who were diagnosed with new-onset PCV and who were followed for a minimum of 6 months. Patients received three monthly intravitreal injections of 0.5 mg ranibizumab or 1.25 mg bevacizumab, at baseline, month 1, and month 2. "Good responders" were defined as those who showed complete resolution of subretinal and/or intraretinal fluid at month 3 after the loading injections, whereas "poor responders" were defined as those who showed persistent retinal fluid on optical coherence tomography (OCT) at month 3 after treatment. Differences in best-corrected visual acuity, indocyanine green angiography, and spectral domain-OCT findings at baseline were analyzed between the two groups. The mean patient age was 68.2 ± 9.7 years, and the mean follow-up period was 27 ± 21 months. The mean subfoveal choroidal thickness was 273 ± 117 μm, and choroidal vascular hyperpermeability was observed in 35 eyes (53.0 %). Thirty-three eyes (50 %) showed good response to treatment, and a thinner subfoveal choroid at baseline significantly correlated with favorable treatment response (P = 0.024). However, there was no significant relationship between treatment response and choroidal vascular hyperpermeability (P = 0.999). The subfoveal choroid was found to be significantly thinner among patients who achieved complete resolution of macular exudation after three loading injections of anti-VEGF agents.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 8%
Unknown 11 92%

Demographic breakdown

Readers by professional status Count As %
Other 4 33%
Student > Postgraduate 1 8%
Student > Bachelor 1 8%
Professor 1 8%
Lecturer 1 8%
Other 4 33%
Readers by discipline Count As %
Medicine and Dentistry 6 50%
Unspecified 3 25%
Nursing and Health Professions 1 8%
Immunology and Microbiology 1 8%
Agricultural and Biological Sciences 1 8%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2015.
All research outputs
#10,833,243
of 12,220,741 outputs
Outputs from Graefe's Archive of Clinical & Experimental Ophthalmology
#902
of 1,228 outputs
Outputs of similar age
#257,938
of 317,092 outputs
Outputs of similar age from Graefe's Archive of Clinical & Experimental Ophthalmology
#27
of 60 outputs
Altmetric has tracked 12,220,741 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,228 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.