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High throughput de novo RNA sequencing elucidates novel responses in Penicillium chrysogenum under microgravity

Overview of attention for article published in Bioprocess and Biosystems Engineering, November 2015
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  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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4 tweeters
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1 Facebook page

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12 Mendeley
Title
High throughput de novo RNA sequencing elucidates novel responses in Penicillium chrysogenum under microgravity
Published in
Bioprocess and Biosystems Engineering, November 2015
DOI 10.1007/s00449-015-1506-4
Pubmed ID
Authors

Yesupatham Sathishkumar, Chandran Krishnaraj, Kalyanaraman Rajagopal, Dwaipayan Sen, Yang Soo Lee

Abstract

In this study, the transcriptional alterations in Penicillium chrysogenum under simulated microgravity conditions were analyzed for the first time using an RNA-Seq method. The increasing plethora of eukaryotic microbial flora inside the spaceship demands the basic understanding of fungal biology in the absence of gravity vector. Penicillium species are second most dominant fungal contaminant in International Space Station. Penicillium chrysogenum an industrially important organism also has the potential to emerge as an opportunistic pathogen for the astronauts during the long-term space missions. But till date, the cellular mechanisms underlying the survival and adaptation of Penicillium chrysogenum to microgravity conditions are not clearly elucidated. A reference genome for Penicillium chrysogenum is not yet available in the NCBI database. Hence, we performed comparative de novo transcriptome analysis of Penicillium chrysogenum grown under microgravity versus normal gravity. In addition, the changes due to microgravity are documented at the molecular level. Increased response to the environmental stimulus, changes in the cell wall component ABC transporter/MFS transporters are noteworthy. Interestingly, sustained increase in the expression of Acyl-coenzyme A: isopenicillin N acyltransferase (Acyltransferase) under microgravity revealed the significance of gravity in the penicillin production which could be exploited industrially.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 42%
Researcher 2 17%
Student > Master 1 8%
Other 1 8%
Student > Bachelor 1 8%
Other 2 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 33%
Biochemistry, Genetics and Molecular Biology 2 17%
Computer Science 1 8%
Unspecified 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Other 3 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2015.
All research outputs
#7,847,769
of 13,018,224 outputs
Outputs from Bioprocess and Biosystems Engineering
#253
of 548 outputs
Outputs of similar age
#168,818
of 353,320 outputs
Outputs of similar age from Bioprocess and Biosystems Engineering
#4
of 30 outputs
Altmetric has tracked 13,018,224 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 548 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,320 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.