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miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1

Overview of attention for article published in Tumor Biology, November 2015
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  • Average Attention Score compared to outputs of the same age
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
3 tweeters

Citations

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21 Dimensions

Readers on

mendeley
10 Mendeley
Title
miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1
Published in
Tumor Biology, November 2015
DOI 10.1007/s13277-015-4425-8
Pubmed ID
Authors

Zhiju Zhao, Limei Qin, Shu Li

Abstract

Lung cancer is the leading cause of cancer deaths worldwide; the study of microRNAs gives new hope for lung cancer treatment. miR-411 has been demonstrated to be an independent prognostic factor for lung adenocarcinoma, but the role and regulatory mechanism are largely unknown. In the present study, we found miR-411 was overexpressed in the lung cancer cells; overexpression of miR-411 promoted anchorage-dependent and anchorage-independent growths of lung cancer, while miR-411 knockdown reduced this effect. Further study showed forkhead box O1 (FOXO1) was a target of miR-411. Overexpression of miR-411 suppressed the expression of FOXO1; the effect of suppression was abrogated when the mutation occurred in the 3'UTR of FOXO1. Knockdown of FOXO1 in cells which miR-411 was inhibited recapitulated the phenotype of miR-411 overexpression. Taken together, our study revealed miR-411 promoted cell proliferation of lung cancer by targeting tumor suppressor gene FOXO1 and miR-411 might be a potential target for lung cancer therapy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 10%
Unknown 9 90%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Researcher 2 20%
Student > Ph. D. Student 2 20%
Student > Postgraduate 1 10%
Student > Bachelor 1 10%
Other 1 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 60%
Agricultural and Biological Sciences 3 30%
Medicine and Dentistry 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2015.
All research outputs
#7,492,639
of 12,428,247 outputs
Outputs from Tumor Biology
#660
of 2,359 outputs
Outputs of similar age
#158,723
of 333,990 outputs
Outputs of similar age from Tumor Biology
#30
of 299 outputs
Altmetric has tracked 12,428,247 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,359 research outputs from this source. They receive a mean Attention Score of 1.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,990 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 299 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.