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Vascular invasion in hepatitis B virus-related hepatocellular carcinoma with underlying cirrhosis: possible associations with ascites and hepatitis B viral factors?

Overview of attention for article published in Tumor Biology, April 2015
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Title
Vascular invasion in hepatitis B virus-related hepatocellular carcinoma with underlying cirrhosis: possible associations with ascites and hepatitis B viral factors?
Published in
Tumor Biology, April 2015
DOI 10.1007/s13277-015-3311-8
Pubmed ID
Authors

Chuan Chen, Dong-Ping Chen, Yan-Yan Gu, Liang-Hao Hu, Dan Wang, Jin-Huan Lin, Zhao-Shen Li, Jing Xu, Ge Wang

Abstract

Vascular invasion is one of the most important prognostic factors for patients with hepatocellular carcinoma (HCC). The objective of the current, retrospective study was to determine the associations of ascites and hepatitis B viral factors (HBeAg and anti-HBe status and HBV DNA levels), as well as tumor-related factors (size, tumor number, grade, and location) with micro- or macroscopic vascular invasion in patients with HCC that developed as a result of hepatitis B virus (HBV)-related cirrhosis. A total of 336 consecutive patients were included. Potential factors associated with micro- or macroscopic vascular invasion were analyzed by logistic regression. Ascites were more commonly detected in patients with micro- or macroscopic vascular invasion, and the presence of ascites was independently associated with vascular invasion. Among patients with mild-to-moderate or severe ascites, the odds ratio for macroscopic vascular invasion was 4.83 (95 % confidence interval [CI] 2.29-10.16) and 11.87 (95 % CI 4.53-31.07), respectively. Similarly, the presence of ascites was associated with microscopic vascular invasion (OR 5.00; 95 % CI 1.23-20.31). In contrast, hepatitis B viral factors were not significantly associated with vascular invasion. The presence of ascites was associated with vascular invasion in patients with HBV-related cirrhotic HCC. Thus, patients with ascites, vascular invasion should be considered and more frequent surveillance should be performed after curative treatment.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 17%
Unknown 5 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 33%
Student > Master 1 17%
Student > Bachelor 1 17%
Student > Postgraduate 1 17%
Unspecified 1 17%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 3 50%
Nursing and Health Professions 1 17%
Social Sciences 1 17%
Unspecified 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#11,047,307
of 12,428,247 outputs
Outputs from Tumor Biology
#1,488
of 2,359 outputs
Outputs of similar age
#269,889
of 331,282 outputs
Outputs of similar age from Tumor Biology
#133
of 282 outputs
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