| Title |
Personalizing blood pressure management in septic shock
|
|---|---|
| Published in |
Annals of Intensive Care, November 2015
|
| DOI | 10.1186/s13613-015-0085-5 |
| Pubmed ID | |
| Authors |
Ryotaro Kato, Michael R. Pinsky |
| Abstract |
This review examines the available evidence for targeting a specific mean arterial pressure (MAP) in sepsis resuscitation. The clinical data suggest that targeting an MAP of 65-70 mmHg in patients with septic shock who do not have chronic hypertension is a reasonable first approximation. Whereas in patients with chronic hypertension, targeting a higher MAP of 80-85 mmHg minimizes renal injury, but it comes with increased risk of arrhythmias. Importantly, MAP alone should not be used as a surrogate of organ perfusion pressure, especially under conditions in which intracranial, intra-abdominal or tissue pressures may be elevated. Organ-specific perfusion pressure targets include 50-70 mmHg for the brain based on trauma brain injury as a surrogate for sepsis, 65 mmHg for renal perfusion and >50 mmHg for hepato-splanchnic flow. Even at the same MAP, organs and regions within organs may have different perfusion pressure and pressure-flow relationships. Thus, once this initial MAP target is achieved, MAP should be titrated up or down based on the measures of organ function and tissue perfusion. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 10% |
| Spain | 2 | 10% |
| Belgium | 2 | 10% |
| United States | 2 | 10% |
| Russia | 1 | 5% |
| Nepal | 1 | 5% |
| Malaysia | 1 | 5% |
| Singapore | 1 | 5% |
| Poland | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 5 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 65% |
| Scientists | 4 | 20% |
| Practitioners (doctors, other healthcare professionals) | 3 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 2 | <1% |
| United States | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 207 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 26 | 12% |
| Other | 25 | 12% |
| Researcher | 23 | 11% |
| Student > Ph. D. Student | 21 | 10% |
| Student > Master | 19 | 9% |
| Other | 55 | 26% |
| Unknown | 42 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 132 | 63% |
| Agricultural and Biological Sciences | 7 | 3% |
| Nursing and Health Professions | 7 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Engineering | 5 | 2% |
| Other | 12 | 6% |
| Unknown | 43 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#1,666,059
of 24,807,923 outputs
Outputs from Annals of Intensive Care
#201
of 1,145 outputs
Outputs of similar age
#21,562
of 258,017 outputs
Outputs of similar age from Annals of Intensive Care
#2
of 28 outputs
Altmetric has tracked 24,807,923 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,145 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.5. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,017 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.