IBS is poorly understood & difficult to treat. Lin & Yi from China report TMEM16A, a calcium-activated chloride channel, is upregulated in colon smooth muscle in a rat model of IBS, providing new therapeutic targets for disease treatment. Open Acc
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RT @FGIFYI: TMEM16-A-pos neurons in the myenteric plexus incr in rat colon's after chronic stress exposure, as did intestinal transit time…
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RT @FGIFYI: TMEM16-A-pos neurons in the myenteric plexus incr in rat colon's after chronic stress exposure, as did intestinal transit time…
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TMEM16-A-pos neurons in the myenteric plexus incr in rat colon's after chronic stress exposure, as did intestinal transit time (ITT) and fecal water content (FWC), when compared to controls. Pharma blockade of TMEM16A caused enhanced ITT & FWC to decli