| Title |
The quest for fragile X biomarkers
|
|---|---|
| Published in |
Molecular and Cellular Pediatrics, September 2014
|
| DOI | 10.1186/s40348-014-0001-3 |
| Pubmed ID | |
| Authors |
Cara J Westmark |
| Abstract |
Fragile X is the most common form of inherited intellectual disability and the leading known genetic cause of autism. There is currently no cure or approved medication for fragile X although various drugs target specific disease symptoms and a large number of therapeutics are in various stages of clinical development. Multiple recent clinical trials have failed on their primary endpoints indicating that there is a compelling need for validated biomarkers and outcome measures in fragile X. There are currently no validated blood-based biomarkers to assess disease severity or to monitor drug efficacy in fragile X syndrome. Herein, we review candidate blood protein biomarkers including extracellular-regulated kinase, phosphoinositide 3-kinase, matrix metalloproteinase 9, amyloid-beta and amyloid-beta protein precursor. Bench-to-bedside plans for fragile X syndrome are severely limited by the lack of validated outcome measures. The reviewed candidate biomarkers are at early stages of validation and deserve further investigation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 21% |
| Student > Ph. D. Student | 7 | 18% |
| Student > Bachelor | 4 | 11% |
| Other | 4 | 11% |
| Student > Master | 4 | 11% |
| Other | 4 | 11% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 21% |
| Neuroscience | 6 | 16% |
| Psychology | 5 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Chemistry | 3 | 8% |
| Other | 6 | 16% |
| Unknown | 6 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2023.
All research outputs
#7,484,502
of 24,129,125 outputs
Outputs from Molecular and Cellular Pediatrics
#24
of 101 outputs
Outputs of similar age
#71,410
of 242,234 outputs
Outputs of similar age from Molecular and Cellular Pediatrics
#2
of 4 outputs
Altmetric has tracked 24,129,125 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 101 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 77% of its peers.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.