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Towards Ni(II) complexes with spin switches for 19F MR-based pH sensing

Overview of attention for article published in Magnetic Resonance Materials in Biology, Physics, & Medicine, September 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)

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Title
Towards Ni(II) complexes with spin switches for 19F MR-based pH sensing
Published in
Magnetic Resonance Materials in Biology, Physics, & Medicine, September 2018
DOI 10.1007/s10334-018-0698-4
Pubmed ID
Authors

Da Xie, Lauren E. Ohman, Emily L. Que

Abstract

Our aim was to demonstrate the potential of exploiting simultaneous changes in coordination geometry and spin state in fluorinated Ni(II) complexes as an avenue for 19F magnetic-resonance (MR)-based pH sensing. Crystal structures were studied using an Agilent Technologies SuperNova Dual Source diffractometer. Solution magnetic moment was determined using Evan's method. MR images were collected on a 7.0-T MR scanner equipped with a quadrature 19F volume coil. NiL1 and NiL2 were synthesized; crystallographic and spectroscopic data supported NiL1 as being diamagnetic and NiL2 as being paramagnetic. In aqueous solution, ligand dissociation from Ni(II) center was observed for both complexes at around pH 6, precluding their use as reversible pH sensors. The two complexes have distinct 19F nuclear magnetic resonance (NMR) signals in terms of both chemical shift and relaxation times, and selective imaging of the two complexes was achieved with no signal interference using two 19F MRI pulse sequences. The significant difference in the chemical shift and relaxation times between NiL1 and NiL2 allowed selective imaging of these species using 19F MRI. While NiL1 and NiL2 were not stable to acidic environments, this report lays the framework for development of improved ligand scaffolds that stably coordinate Ni(II) in acidic aqueous solution and act as agents for ratiometric pH mapping by 19F MRI.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 1 33%
Student > Postgraduate 1 33%
Student > Doctoral Student 1 33%
Readers by discipline Count As %
Unspecified 1 33%
Physics and Astronomy 1 33%
Chemistry 1 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2018.
All research outputs
#3,612,222
of 12,593,681 outputs
Outputs from Magnetic Resonance Materials in Biology, Physics, & Medicine
#69
of 252 outputs
Outputs of similar age
#100,403
of 269,415 outputs
Outputs of similar age from Magnetic Resonance Materials in Biology, Physics, & Medicine
#1
of 2 outputs
Altmetric has tracked 12,593,681 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 252 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,415 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them