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Cytotoxic compounds from Laurencia pacifica

Overview of attention for article published in Organic and Medicinal Chemistry Letters, September 2014
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Title
Cytotoxic compounds from Laurencia pacifica
Published in
Organic and Medicinal Chemistry Letters, September 2014
DOI 10.1186/s13588-014-0008-8
Pubmed ID
Authors

Diana A Zaleta-Pinet, Ian P Holland, Mauricio Muñoz-Ochoa, J Ivan Murillo-Alvarez, Jennette A Sakoff, Ian A van Altena, Adam McCluskey

Abstract

The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica. This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 μM. Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development. Graphical Abstract ᅟ.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 27%
Student > Ph. D. Student 4 15%
Researcher 3 12%
Student > Bachelor 3 12%
Student > Doctoral Student 2 8%
Other 4 15%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 5 19%
Chemistry 4 15%
Medicine and Dentistry 4 15%
Earth and Planetary Sciences 1 4%
Other 3 12%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2015.
All research outputs
#4,848,542
of 6,554,440 outputs
Outputs from Organic and Medicinal Chemistry Letters
#4
of 12 outputs
Outputs of similar age
#143,650
of 209,323 outputs
Outputs of similar age from Organic and Medicinal Chemistry Letters
#1
of 1 outputs
Altmetric has tracked 6,554,440 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12 research outputs from this source. They receive a mean Attention Score of 2.7. This one scored the same or higher as 8 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,323 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them