| Title |
Cytotoxic compounds from Laurencia pacifica
|
|---|---|
| Published in |
BMC Chemistry, September 2014
|
| DOI | 10.1186/s13588-014-0008-8 |
| Pubmed ID | |
| Authors |
Diana A Zaleta-Pinet, Ian P Holland, Mauricio Muñoz-Ochoa, J Ivan Murillo-Alvarez, Jennette A Sakoff, Ian A van Altena, Adam McCluskey |
| Abstract |
The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica. This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 μM. Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development. Graphical Abstract ᅟ. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 28% |
| Student > Ph. D. Student | 6 | 21% |
| Researcher | 3 | 10% |
| Other | 2 | 7% |
| Student > Doctoral Student | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 24% |
| Biochemistry, Genetics and Molecular Biology | 5 | 17% |
| Chemistry | 4 | 14% |
| Medicine and Dentistry | 4 | 14% |
| Unspecified | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 5 | 17% |