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Structural and dynamic changes in mitochondria of rat myocardium under acute hypoxic hypoxia: Role of mitochondrial ATP-dependent potassium channel

Overview of attention for article published in Biochemistry (00062979), August 2015
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Title
Structural and dynamic changes in mitochondria of rat myocardium under acute hypoxic hypoxia: Role of mitochondrial ATP-dependent potassium channel
Published in
Biochemistry (00062979), August 2015
DOI 10.1134/s0006297915080040
Pubmed ID
Authors

E. V. Rozova, I. N. Mankovskaya, G. D. Mironova

Abstract

The ultrastructure and spatial localization of mitochondria (MC) in the myocardium of rats exposed to a 30-min hypoxic hypoxia were investigated. The mitochondrial structure was found to undergo changes; however, marked necrotic injuries were not observed. Changes occurring in the myocardium are aimed at the intensification of energy processes. This shows up as an increase in the number of MC in the subsarcolemmal zone of the myocardium and changes in the surface of the sublemmal membrane due to its bending around mitochondria, which improves the diffusion of oxygen into MC. In addition, the division of MC is enhanced, which partially explains the increase in their total number. In structurally altered MC with intact membrane, electron dense formations with small diameter appear, which probably represent newly formed organelles (microMC). In normoxia, changes of this kind do not occur. It was found that the ATP-dependent K+ channel is involved in the regulation of the morphological state of MC under hypoxic hypoxia. The activator of the channel diazoxide increases the number of newly formed microMC, and the channel inhibitor 5HD significantly prevents their formation. Possible mechanisms of structural and dynamic changes in rat myocardial MC under acute hypoxic hypoxia are discussed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 50%
Student > Bachelor 2 20%
Student > Ph. D. Student 1 10%
Librarian 1 10%
Student > Postgraduate 1 10%
Other 0 0%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 30%
Agricultural and Biological Sciences 2 20%
Social Sciences 1 10%
Medicine and Dentistry 1 10%
Neuroscience 1 10%
Other 1 10%
Unknown 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2015.
All research outputs
#10,919,465
of 12,322,056 outputs
Outputs from Biochemistry (00062979)
#18,406
of 19,080 outputs
Outputs of similar age
#217,260
of 265,549 outputs
Outputs of similar age from Biochemistry (00062979)
#126
of 153 outputs
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