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Pin1 promotes prostate cancer cell proliferation and migration through activation of Wnt/β-catenin signaling

Overview of attention for article published in Clinical and Translational Oncology, October 2015
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10 Mendeley
Title
Pin1 promotes prostate cancer cell proliferation and migration through activation of Wnt/β-catenin signaling
Published in
Clinical and Translational Oncology, October 2015
DOI 10.1007/s12094-015-1431-7
Pubmed ID
Authors

Z. Zhu, H. Zhang, F. Lang, G. Liu, D. Gao, B. Li, Y. Liu

Abstract

Recent evidence suggests that the peptidyl-prolyl isomerase Pin1 is an oncoprotein that acts as a novel therapeutic target in a variety of tumors. In this study, we investigated the clinical significance of Pin1 and its function in prostate cancer (PCa) tumor progression. Immunohistochemical and quantitative RT-PCR analyses were performed to detect the expression of Pin1 in 86 PCa tissue samples. The functional role of Pin1 was evaluated by small interfering RNA-mediated depletion in PCa cells followed by analyses of cell proliferation and migration. Furthermore, the association between expression of Pin1 and levels of β-catenin and cyclin D1 was also evaluated. Our results showed that the high expression of Pin1 staining was 66 of 86 (76.74 %) PCa samples, and in 25 of 86 (29.07 %) BPH tissues, the difference was statistically significant (P < 0.001). Pin1 was significantly elevated in all PCa cell lines when compared to the normal RWPE-1 cells. We observed that proliferation and migration of LNCaP cells were inhibited by Pin1 knockdown. The levels of β-catenin and cyclin D1 in clinical PCa specimens were positively associated with Pin1 expression. Our results suggest that Pin1 plays an important role in tumorigenesis of PCa, suggesting that targeting Pin1 pathway could represent a potential modality for treating PCa.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 10%
Unknown 9 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 30%
Student > Bachelor 2 20%
Student > Master 2 20%
Researcher 2 20%
Student > Doctoral Student 1 10%
Other 0 0%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 50%
Agricultural and Biological Sciences 3 30%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Medicine and Dentistry 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2015.
All research outputs
#10,391,745
of 13,029,564 outputs
Outputs from Clinical and Translational Oncology
#412
of 653 outputs
Outputs of similar age
#194,330
of 281,831 outputs
Outputs of similar age from Clinical and Translational Oncology
#8
of 25 outputs
Altmetric has tracked 13,029,564 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 653 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,831 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.