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Burkholderia pseudomallei-absent soil bacterial community results in secondary metabolites that kill this pathogen

Overview of attention for article published in AMB Express, August 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#50 of 1,171)
  • Good Attention Score compared to outputs of the same age (78th percentile)

Mentioned by

blogs
1 blog
twitter
6 tweeters

Citations

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2 Dimensions

Readers on

mendeley
20 Mendeley
Title
Burkholderia pseudomallei-absent soil bacterial community results in secondary metabolites that kill this pathogen
Published in
AMB Express, August 2018
DOI 10.1186/s13568-018-0663-7
Pubmed ID
Authors

Chotima Potisap, Md Abdul Wadud Khan, Atcha Boonmee, Jorge L. M. Rodrigues, Surasakdi Wongratanacheewin, Rasana W. Sermswan

Abstract

Burkholderia pseudomallei is a Gram-negative bacterium found in soil and the causative agent of a severe disease in humans and animals known as melioidosis. It is intrinsically resistant to many antibiotics and has been reported resistant to the drugs of choice; ceftazidime. Microbial communities in soil in the presence and absence of B. pseudomallei were investigated using metagenomics approach. The variation in bacterial species diversity was significantly higher in soil samples without B. pseudomallei. Abundances of phyla Actinobacteria and Firmicutes were found significantly higher in B. pseudomallei-negative soils. Bacillus amyloliquefaciens KKU1 in phylum Firmicutes was discovered from negative soil and its secondary metabolites could inhibit clinical, environmental and drug resistant isolates of B. pseudomallei, together with some pathogenic Gram-negative but not Gram-positive bacteria. The antimicrobial activity from KKU 1 against B. pseudomallei was abolished when treated with proteinase K, stable in a wide range of pH and remained active after heating at 100 °C for 15 min. Precipitated proteins from KKU1 were demonstrated to cause lysis and corrugated surfaces of B. pseudomallei. The minimum inhibitory concentrations and minimum bactericidal concentrations of the precipitated proteins from KKU1 against B. pseudomallei were 0.97 μg/ml and 3.9 μg/ml. Interestingly, Native SDS-PAGE showed small active compounds of less than 6 kDa, along with other information collectively suggesting the properties of antimicrobial peptides. For the first time, culture-independent information in melioidosis endemic area could lead to a suspected source of metabolites that may help defense against B. pseudomallei and other pathogenic Gram-negative bacteria.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 15%
Lecturer 2 10%
Student > Master 2 10%
Researcher 2 10%
Student > Ph. D. Student 2 10%
Other 3 15%
Unknown 6 30%
Readers by discipline Count As %
Immunology and Microbiology 4 20%
Biochemistry, Genetics and Molecular Biology 3 15%
Unspecified 1 5%
Arts and Humanities 1 5%
Computer Science 1 5%
Other 3 15%
Unknown 7 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2018.
All research outputs
#3,245,332
of 21,194,338 outputs
Outputs from AMB Express
#50
of 1,171 outputs
Outputs of similar age
#62,573
of 296,497 outputs
Outputs of similar age from AMB Express
#1
of 1 outputs
Altmetric has tracked 21,194,338 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,171 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,497 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them