Title |
Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy
|
---|---|
Published in |
BMC Medical Genomics, April 2011
|
DOI | 10.1186/1755-8794-4-36 |
Pubmed ID | |
Authors |
Dwi U Kemaladewi, Willem MH Hoogaars, Sandra H van Heiningen, Samuel Terlouw, David JJ de Gorter, Johan T den Dunnen, Gert Jan B van Ommen, Annemieke Aartsma-Rus, Peter ten Dijke, Peter AC 't Hoen |
Abstract |
Myostatin is a potent muscle growth inhibitor that belongs to the Transforming Growth Factor-β (TGF-β) family. Mutations leading to non functional myostatin have been associated with hypermuscularity in several organisms. By contrast, Duchenne muscular dystrophy (DMD) is characterized by a loss of muscle fibers and impaired regeneration. In this study, we aim to knockdown myostatin by means of exon skipping, a technique which has been successfully applied to reframe the genetic defect of dystrophin gene in DMD patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Russia | 1 | 1% |
Italy | 1 | 1% |
Unknown | 70 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 26% |
Student > Ph. D. Student | 13 | 18% |
Professor | 6 | 8% |
Student > Bachelor | 6 | 8% |
Student > Postgraduate | 4 | 5% |
Other | 15 | 21% |
Unknown | 10 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 38% |
Medicine and Dentistry | 12 | 16% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Neuroscience | 2 | 3% |
Chemistry | 2 | 3% |
Other | 9 | 12% |
Unknown | 12 | 16% |