| Title |
Genetics of Severe Obesity
|
|---|---|
| Published in |
Current Diabetes Reports, August 2018
|
| DOI | 10.1007/s11892-018-1053-x |
| Pubmed ID | |
| Authors |
Una Fairbrother, Elliot Kidd, Tanya Malagamuwa, Andrew Walley |
| Abstract |
This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R. There is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency of some of the identified variants, it is clear that monogenic variants also make a significant contribution to common obesity. The artificial distinction between rare monogenic obesity and common polygenic obesity is now obsolete with the identification of MC4R variants of strong effect in the general population. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 7 | 25% |
| United Kingdom | 5 | 18% |
| United States | 4 | 14% |
| Comoros | 1 | 4% |
| Sweden | 1 | 4% |
| Mexico | 1 | 4% |
| France | 1 | 4% |
| Colombia | 1 | 4% |
| Unknown | 7 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 54% |
| Scientists | 7 | 25% |
| Practitioners (doctors, other healthcare professionals) | 6 | 21% |
Mendeley readers
The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 186 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 12% |
| Student > Bachelor | 23 | 12% |
| Researcher | 21 | 11% |
| Student > Ph. D. Student | 21 | 11% |
| Other | 8 | 4% |
| Other | 16 | 9% |
| Unknown | 74 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 37 | 20% |
| Medicine and Dentistry | 21 | 11% |
| Agricultural and Biological Sciences | 11 | 6% |
| Nursing and Health Professions | 10 | 5% |
| Neuroscience | 5 | 3% |
| Other | 23 | 12% |
| Unknown | 79 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2023.
All research outputs
#1,573,483
of 25,134,448 outputs
Outputs from Current Diabetes Reports
#80
of 1,046 outputs
Outputs of similar age
#32,300
of 338,919 outputs
Outputs of similar age from Current Diabetes Reports
#4
of 43 outputs
Altmetric has tracked 25,134,448 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,046 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,919 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.