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Differential dopamine function in fibromyalgia

Overview of attention for article published in Brain Imaging and Behavior, October 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

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1 news outlet
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4 X users
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1 Facebook page

Citations

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45 Dimensions

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114 Mendeley
Title
Differential dopamine function in fibromyalgia
Published in
Brain Imaging and Behavior, October 2015
DOI 10.1007/s11682-015-9459-4
Pubmed ID
Authors

Daniel S. Albrecht, Palmer J. MacKie, David A. Kareken, Gary D. Hutchins, Evgeny J. Chumin, Bradley T. Christian, Karmen K. Yoder

Abstract

Approximately 30 % of Americans suffer from chronic pain disorders, such as fibromyalgia (FM), which can cause debilitating pain. Many pain-killing drugs prescribed for chronic pain disorders are highly addictive, have limited clinical efficacy, and do not treat the cognitive symptoms reported by many patients. The neurobiological substrates of chronic pain are largely unknown, but evidence points to altered dopaminergic transmission in aberrant pain perception. We sought to characterize the dopamine (DA) system in individuals with FM. Positron emission tomography (PET) with [(18)F]fallypride (FAL) was used to assess changes in DA during a working memory challenge relative to a baseline task, and to test for associations between baseline D2/D3 availability and experimental pain measures. Twelve female subjects with FM and 11 female controls completed study procedures. Subjects received one FAL PET scan while performing a "2-back" task, and one while performing a "0-back" (attentional control, "baseline") task. FM subjects had lower baseline FAL binding potential (BP) in several cortical regions relative to controls, including anterior cingulate cortex. In FM subjects, self-reported spontaneous pain negatively correlated with FAL BP in the left orbitofrontal cortex and parahippocampal gyrus. Baseline BP was significantly negatively correlated with experimental pain sensitivity and tolerance in both FM and CON subjects, although spatial patterns of these associations differed between groups. The data suggest that abnormal DA function may be associated with differential processing of pain perception in FM. Further studies are needed to explore the functional significance of DA in nociception and cognitive processing in chronic pain.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Unknown 113 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 12%
Student > Master 14 12%
Student > Ph. D. Student 13 11%
Student > Bachelor 11 10%
Student > Postgraduate 9 8%
Other 23 20%
Unknown 30 26%
Readers by discipline Count As %
Neuroscience 20 18%
Medicine and Dentistry 18 16%
Psychology 16 14%
Nursing and Health Professions 8 7%
Agricultural and Biological Sciences 3 3%
Other 17 15%
Unknown 32 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2022.
All research outputs
#2,414,830
of 22,830,751 outputs
Outputs from Brain Imaging and Behavior
#115
of 1,155 outputs
Outputs of similar age
#36,546
of 283,725 outputs
Outputs of similar age from Brain Imaging and Behavior
#4
of 29 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,155 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,725 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.