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Differential dopamine function in fibromyalgia

Overview of attention for article published in Brain Imaging and Behavior, October 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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4 tweeters
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1 Facebook page

Citations

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18 Dimensions

Readers on

mendeley
53 Mendeley
Title
Differential dopamine function in fibromyalgia
Published in
Brain Imaging and Behavior, October 2015
DOI 10.1007/s11682-015-9459-4
Pubmed ID
Authors

Daniel S. Albrecht, Palmer J. MacKie, David A. Kareken, Gary D. Hutchins, Evgeny J. Chumin, Bradley T. Christian, Karmen K. Yoder

Abstract

Approximately 30 % of Americans suffer from chronic pain disorders, such as fibromyalgia (FM), which can cause debilitating pain. Many pain-killing drugs prescribed for chronic pain disorders are highly addictive, have limited clinical efficacy, and do not treat the cognitive symptoms reported by many patients. The neurobiological substrates of chronic pain are largely unknown, but evidence points to altered dopaminergic transmission in aberrant pain perception. We sought to characterize the dopamine (DA) system in individuals with FM. Positron emission tomography (PET) with [(18)F]fallypride (FAL) was used to assess changes in DA during a working memory challenge relative to a baseline task, and to test for associations between baseline D2/D3 availability and experimental pain measures. Twelve female subjects with FM and 11 female controls completed study procedures. Subjects received one FAL PET scan while performing a "2-back" task, and one while performing a "0-back" (attentional control, "baseline") task. FM subjects had lower baseline FAL binding potential (BP) in several cortical regions relative to controls, including anterior cingulate cortex. In FM subjects, self-reported spontaneous pain negatively correlated with FAL BP in the left orbitofrontal cortex and parahippocampal gyrus. Baseline BP was significantly negatively correlated with experimental pain sensitivity and tolerance in both FM and CON subjects, although spatial patterns of these associations differed between groups. The data suggest that abnormal DA function may be associated with differential processing of pain perception in FM. Further studies are needed to explore the functional significance of DA in nociception and cognitive processing in chronic pain.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Unspecified 11 21%
Student > Master 11 21%
Researcher 7 13%
Student > Ph. D. Student 7 13%
Student > Bachelor 5 9%
Other 12 23%
Readers by discipline Count As %
Unspecified 12 23%
Neuroscience 12 23%
Medicine and Dentistry 9 17%
Psychology 8 15%
Nursing and Health Professions 4 8%
Other 8 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2015.
All research outputs
#3,511,047
of 12,517,134 outputs
Outputs from Brain Imaging and Behavior
#201
of 714 outputs
Outputs of similar age
#80,218
of 275,057 outputs
Outputs of similar age from Brain Imaging and Behavior
#10
of 36 outputs
Altmetric has tracked 12,517,134 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 714 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,057 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.