Title |
From Protecting the Heart to Improving Athletic Performance – the Benefits of Local and Remote Ischaemic Preconditioning
|
---|---|
Published in |
Cardiovascular Drugs and Therapy, October 2015
|
DOI | 10.1007/s10557-015-6621-6 |
Pubmed ID | |
Authors |
Vikram Sharma, Reuben Marsh, Brian Cunniffe, Marco Cardinale, Derek M. Yellon, Sean M. Davidson |
Abstract |
Remote Ischemic Preconditioning (RIPC) is a non-invasive cardioprotective intervention that involves brief cycles of limb ischemia and reperfusion. This is typically delivered by inflating and deflating a blood pressure cuff on one or more limb(s) for several cycles, each inflation-deflation being 3-5 min in duration. RIPC has shown potential for protecting the heart and other organs from injury due to lethal ischemia and reperfusion injury, in a variety of clinical settings. The mechanisms underlying RIPC are under intense investigation but are just beginning to be deciphered. Emerging evidence suggests that RIPC has the potential to improve exercise performance, via both local and remote mechanisms. This review discusses the clinical studies that have investigated the role of RIPC in cardioprotection as well as those studying its applicability in improving athletic performance, while examining the potential mechanisms involved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 10 | 48% |
Qatar | 2 | 10% |
United Arab Emirates | 1 | 5% |
Australia | 1 | 5% |
United States | 1 | 5% |
Comoros | 1 | 5% |
Canada | 1 | 5% |
Switzerland | 1 | 5% |
Saudi Arabia | 1 | 5% |
Other | 0 | 0% |
Unknown | 2 | 10% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 62% |
Scientists | 7 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 2% |
Netherlands | 1 | <1% |
Russia | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 133 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 19% |
Student > Bachelor | 20 | 14% |
Student > Ph. D. Student | 15 | 11% |
Researcher | 14 | 10% |
Student > Doctoral Student | 10 | 7% |
Other | 26 | 19% |
Unknown | 28 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Sports and Recreations | 46 | 33% |
Medicine and Dentistry | 28 | 20% |
Nursing and Health Professions | 9 | 6% |
Biochemistry, Genetics and Molecular Biology | 7 | 5% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 11 | 8% |
Unknown | 34 | 24% |