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Biomarkers of islet beta cell stress and death in type 1 diabetes

Overview of attention for article published in Diabetologia, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
43 tweeters

Citations

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4 Dimensions

Readers on

mendeley
25 Mendeley
Title
Biomarkers of islet beta cell stress and death in type 1 diabetes
Published in
Diabetologia, August 2018
DOI 10.1007/s00125-018-4712-1
Pubmed ID
Authors

Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira

Abstract

Recent work on the pathogenesis of type 1 diabetes has led to an evolving recognition of the heterogeneity of this disease, both with regards to clinical phenotype and responses to therapies to prevent or revert diabetes. This heterogeneity not only limits efforts to accurately predict clinical disease but also is reflected in differing responses to immunomodulatory therapeutics. Thus, there is a need for robust biomarkers of beta cell health, which could provide insight into pathophysiological differences in disease course, improve disease prediction, increase the understanding of therapeutic responses to immunomodulatory interventions and identify individuals most likely to benefit from these therapies. In this review, we outline current literature, limitations and future directions for promising circulating markers of beta cell stress and death in type 1 diabetes, including markers indicating abnormal prohormone processing, circulating RNAs and circulating DNAs.

Twitter Demographics

The data shown below were collected from the profiles of 43 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 20%
Student > Ph. D. Student 4 16%
Student > Postgraduate 4 16%
Professor 3 12%
Student > Master 2 8%
Other 7 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 24%
Medicine and Dentistry 5 20%
Agricultural and Biological Sciences 5 20%
Immunology and Microbiology 2 8%
Unspecified 2 8%
Other 5 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2018.
All research outputs
#621,366
of 13,122,999 outputs
Outputs from Diabetologia
#398
of 3,803 outputs
Outputs of similar age
#24,092
of 266,100 outputs
Outputs of similar age from Diabetologia
#24
of 60 outputs
Altmetric has tracked 13,122,999 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,803 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,100 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.