↓ Skip to main content

Effects of levodopa therapy on voxel-based degree centrality in Parkinson’s disease

Overview of attention for article published in Brain Imaging and Behavior, August 2018
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
6 Mendeley
Title
Effects of levodopa therapy on voxel-based degree centrality in Parkinson’s disease
Published in
Brain Imaging and Behavior, August 2018
DOI 10.1007/s11682-018-9936-7
Pubmed ID
Authors

Miao Zhong, Wanqun Yang, Biao Huang, Wenjie Jiang, Xiong Zhang, Xiaojin Liu, Lijuan Wang, Junjing Wang, Ling Zhao, Yuhu Zhang, Yingjun Liu, Jiabao Lin, Ruiwang Huang

Abstract

Levodopa therapy is widely recognized as an effective treatment for PD patients, however, it is rare of the study looking at effects of levodopa therapy on the whole-brain network. This study was to evaluate the effects of levodopa on whole-brain degree centrality (DC) and seed-based functional connectivity (FC) in PD patients. We recruited 26 PD patients and acquired their resting-state fMRI data before ('OFF' state) and after ('ON' state) taking a dose of 400 mg levodopa. Through constructing the voxel-based brain functional network, we calculated distant and local DC and seed-based FC. We found that compared to the healthy controls, the PD patients at 'OFF' state showed significantly decreased distant DC in several occipital regions and left postcentral gyrus, but increased distant DC in the right precentral gyrus, supplementary motor area, and several frontal regions. Meanwhile, we detected decreased local DC in the left cuneus and bilateral insula but increased local DC in several temporal regions in the PD patients at 'OFF' state compared to the controls. Using paired-sample t-tests, we found that levodopa effectively normalized the distant DC abnormalities in the PD patients particularly in the occipital regions and postcentral gyrus. Additionally, compared to 'OFF' state, the PD patients at 'ON' state showed decreased FC of the left median cingulate gyrus to brain regions in default mode network. The decreased FC of the left median cingulate gyrus to right temporal pole was associated with improved UPDRS-III score. This study provided new evidence for understanding the neural effects of levodopa therapy on the whole-brain network in PD patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 4 67%
Other 1 17%
Researcher 1 17%
Readers by discipline Count As %
Unspecified 6 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2018.
All research outputs
#10,627,696
of 13,352,827 outputs
Outputs from Brain Imaging and Behavior
#590
of 776 outputs
Outputs of similar age
#199,828
of 267,366 outputs
Outputs of similar age from Brain Imaging and Behavior
#19
of 32 outputs
Altmetric has tracked 13,352,827 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 776 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,366 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.