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High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Overview of attention for article published in Tumor Biology, October 2015
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Mentioned by

twitter
1 tweeter

Citations

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27 Dimensions

Readers on

mendeley
8 Mendeley
Title
High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer
Published in
Tumor Biology, October 2015
DOI 10.1007/s13277-015-4141-4
Pubmed ID
Authors

Baoying Yuan, Changshun Wu, Xingwen Wang, Dan Wang, Huiling Liu, Ling Guo, Xiang-An Li, Junqing Han, Hong Feng

Abstract

Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan-Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 38%
Student > Ph. D. Student 2 25%
Student > Postgraduate 1 13%
Researcher 1 13%
Professor > Associate Professor 1 13%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 38%
Unspecified 2 25%
Biochemistry, Genetics and Molecular Biology 1 13%
Immunology and Microbiology 1 13%
Medicine and Dentistry 1 13%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2015.
All research outputs
#9,949,486
of 12,428,247 outputs
Outputs from Tumor Biology
#1,080
of 2,359 outputs
Outputs of similar age
#172,764
of 251,945 outputs
Outputs of similar age from Tumor Biology
#101
of 286 outputs
Altmetric has tracked 12,428,247 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,359 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,945 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 286 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.