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Low agreement between modified-Schwartz and CKD-EPI eGFR in young adults: a retrospective longitudinal cohort study

Overview of attention for article published in BMC Nephrology, August 2018
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)

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Title
Low agreement between modified-Schwartz and CKD-EPI eGFR in young adults: a retrospective longitudinal cohort study
Published in
BMC Nephrology, August 2018
DOI 10.1186/s12882-018-0995-1
Pubmed ID
Authors

Michael Webster-Clark, Byron Jaeger, Yi Zhong, Guido Filler, Ana Alvarez-Elias, Nora Franceschini, Maria E. Díaz-González de Ferris

Abstract

While there is a great deal of research updating methods for estimating renal function, many of these methods are being developed in either adults with CKD or younger children. Currently, there is limited understanding of the agreement between the modified new bedside Schwartz estimated glomerular filtration rate (eGFR) formula and the adult CKD-EPI formula in adolescents and young adults (AYAs) with chronic kidney disease (CKD) measured longitudinally. Longitudinal cohort study of 242 patients (10-30 years) with CKD, followed retrospectively in a single tertiary centre as they transitioned from the paediatric- to adult-focused settings. The study population came from a longitudinal cohort of AYAs undergoing healthcare transition at the STARx Program at the University of North Carolina, in the South-Eastern USA, from 2006 to 2015. We calculated and compared the eGFR using the new bedside Schwartz formula and the CKD-EPI eGFR. Measurements were repeated for each age in years. Agreement was tested using Bland & Altman analysis. Subgroup analysis was performed using the following age groups 10-15, 15-20, 20-25 and 25-30 years, glomerular and non-glomerular causes of CKD and height z-score. Using repeated measures, concordance between the new Schwartz and CKD-EPI eGFR was low at 0.74 (95% C.I. 0.67, 0.79) at the lowest age range of 10-15, 0.78 (95% C.I. 0.71, 0.84) at age 15-20, 0.80 (0.70, 0.87) at ages 20-25, and 0.82 (95% C.I. 0.70, 0.90) at age 25-30. Discordance was worse in males and largest in the 10-15 year-old age group, and in patients with stunted growth. The Schwartz and CKD-EPI equations exhibit poor agreement in patients before and during the transition period with CKD-EPI consistently yielding higher eGFRs, especially in males. Further studies are required to determine the appropriate age for switching to the CKD-EPI equation after age 18.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 50%
Student > Master 1 17%
Professor 1 17%
Unspecified 1 17%
Readers by discipline Count As %
Unspecified 2 33%
Medicine and Dentistry 2 33%
Chemistry 1 17%
Nursing and Health Professions 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2018.
All research outputs
#6,704,290
of 12,452,184 outputs
Outputs from BMC Nephrology
#412
of 1,244 outputs
Outputs of similar age
#119,860
of 268,314 outputs
Outputs of similar age from BMC Nephrology
#1
of 1 outputs
Altmetric has tracked 12,452,184 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,244 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,314 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them