Title |
Receptor tyrosine kinase-Ras-PI 3 kinase-Akt signaling network in glioblastoma multiforme
|
---|---|
Published in |
Medical Oncology, August 2018
|
DOI | 10.1007/s12032-018-1185-5 |
Pubmed ID | |
Authors |
Gulten Tuncel, Rasime Kalkan |
Abstract |
Glioblastoma multiforme (GBM) is the most malignant form of the brain tumors and shows different genetic and epigenetic abnormalities. Gene amplification, genetic instability, disruption of apoptotic pathways, deregulated oncogene expression, invasive phenotypical changes, abnormal angiogenesis, and epigenetic changes have all been described in GBMs. These abnormalities indicate that a number of different signaling pathways are deregulated in GBM. Increasing number of studies provide a better understanding of the tumor biology, genetic, and epigenetic background of the GBM. Also, current research provides us useful approaches in designing novel therapies for GBM. In this review, we summarize the receptor tyrosine kinase-Ras-PI 3 kinase-Akt signaling network, focusing on the potential molecular targets for anti-signaling molecular therapies in this pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 21% |
Student > Bachelor | 5 | 15% |
Student > Master | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Professor > Associate Professor | 3 | 9% |
Other | 3 | 9% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 12 | 35% |
Agricultural and Biological Sciences | 5 | 15% |
Medicine and Dentistry | 5 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 9 | 26% |