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Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids

Overview of attention for article published in Journal of Materials Science: Materials in Medicine, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

twitter
4 tweeters

Citations

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25 Dimensions

Readers on

mendeley
70 Mendeley
Title
Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids
Published in
Journal of Materials Science: Materials in Medicine, October 2015
DOI 10.1007/s10856-015-5591-3
Pubmed ID
Authors

Hideyuki Suenaga, Katsuko S. Furukawa, Yukako Suzuki, Tsuyoshi Takato, Takashi Ushida

Abstract

Mesenchymal stem cell (MSC) condensation contributes to membrane ossification by enhancing their osteodifferentiation. We investigated bone regeneration in rats using the human bone marrow-derived MSC-spheroids prepared by rotation culture, without synthetic or exogenous biomaterials. Bilateral calvarial defects (8 mm) were created in nude male rats; the left-sided defects were implanted with MSC-spheroids, β-tricalcium phosphate (β-TCP) granules, or β-TCP granules + MSC-spheroids, while the right-sided defects served as internal controls. Micro-computed tomography and immunohistochemical staining for osteocalcin/osteopontin indicated formation of new, full-thickness bones at the implantation sites, but not at the control sites in the MSC-spheroid group. Raman spectroscopy revealed similarity in the spectral properties of the repaired bone and native calvarial bone. Mechanical performance of the bones in the MSC-implanted group was good (50 and 60 % those of native bones, respectively). All tests showed poor bone regeneration in the β-TCP and β-TCP + MSC-spheroid groups. Thus, significant bone regeneration was achieved with MSC-spheroid implantation into bone defects, justifying further investigation.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Unspecified 16 23%
Student > Master 12 17%
Student > Bachelor 11 16%
Student > Ph. D. Student 11 16%
Researcher 8 11%
Other 12 17%
Readers by discipline Count As %
Unspecified 22 31%
Medicine and Dentistry 14 20%
Agricultural and Biological Sciences 10 14%
Biochemistry, Genetics and Molecular Biology 9 13%
Engineering 7 10%
Other 8 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2015.
All research outputs
#6,925,011
of 12,319,220 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#610
of 825 outputs
Outputs of similar age
#107,980
of 256,786 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#4
of 13 outputs
Altmetric has tracked 12,319,220 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 825 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,786 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.