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Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice

Overview of attention for article published in Archives of Gynecology & Obstetrics, August 2018
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  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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2 tweeters
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1 Facebook page

Citations

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3 Dimensions

Readers on

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13 Mendeley
Title
Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice
Published in
Archives of Gynecology & Obstetrics, August 2018
DOI 10.1007/s00404-018-4864-8
Pubmed ID
Authors

Thomas Römer

Abstract

Endometriosis is a debilitating disease with high recurrence rates requiring long-term management. Progestins such as dienogest are used empirically when first symptoms occur and post-surgery to reduce recurrence. This retrospective, practice-based study assessed the efficacy and safety of dienogest in women with endometriosis treated for at least 60 months. 37 women (age 39 ± 8 years) with laparoscopically diagnosed endometriosis received dienogest 2 mg orally once daily. Endometriosis-associated pelvic pain (EAPP) was measured on a 0-100 mm visual analog scale at baseline and every 12 months. Laboratory measures of lipid and liver metabolism, hemostatic and hormonal parameters were investigated in a subgroup of 15 women. Adverse events including bleeding disturbances and depressive symptoms were recorded. In 22 women, dienogest was begun after laparoscopy; median EAPP score was 70 mm pre-surgery and 10, 10, 20, 20, and 20 mm, respectively, after 12, 24, 36, 48, and 60 months of dienogest treatment. Another 15 women began dienogest without prior surgery; median EAPP score was 80 mm pretreatment and 20, 20, 30, 30, and 30 mm, respectively, after 12, 24, 36, 48, and 60 months. All laboratory parameters remained within the normal range. Mean serum estradiol was 28 ± 12 pg/ml after 60 months. Seven women experienced spotting episodes and four women presented with phases of depressed mood, which could all be clinically managed. Long-term (60-month) treatment with dienogest 2 mg once-daily in women with endometriosis effectively reduced EAPP and avoided pain recurrence post-surgery. Dienogest was well tolerated and adverse effects were clinically managed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 23%
Student > Bachelor 2 15%
Student > Postgraduate 2 15%
Student > Doctoral Student 2 15%
Unspecified 2 15%
Other 2 15%
Readers by discipline Count As %
Medicine and Dentistry 5 38%
Agricultural and Biological Sciences 2 15%
Unspecified 2 15%
Business, Management and Accounting 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Other 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2019.
All research outputs
#8,500,644
of 13,543,741 outputs
Outputs from Archives of Gynecology & Obstetrics
#595
of 1,163 outputs
Outputs of similar age
#160,094
of 266,961 outputs
Outputs of similar age from Archives of Gynecology & Obstetrics
#11
of 28 outputs
Altmetric has tracked 13,543,741 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,163 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,961 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.