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Stem cell aging in adult progeria

Overview of attention for article published in Cell Regeneration, January 2015
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2 tweeters


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53 Mendeley
Stem cell aging in adult progeria
Published in
Cell Regeneration, January 2015
DOI 10.1186/s13619-015-0021-z
Pubmed ID

Hoi-Hung Cheung, Duanqing Pei, Wai-Yee Chan


Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development of cardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become the focus in aging research. Natural aging is not regarded as a programmed process. However, accelerated aging due to inherited genetic defects in patients of progeria is programmed and resembles many aspects of natural aging. Among several premature aging syndromes, Werner syndrome (WS) and Hutchinson-Gilford progeria syndrome (HGPS) are two broadly investigated diseases. In this review, we discuss how stem cell aging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigenetic landscape in aged cells can be reversed to a "juvenile" state. Lastly, we explore the potential application of the latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 23%
Researcher 10 19%
Student > Master 7 13%
Student > Ph. D. Student 6 11%
Other 5 9%
Other 4 8%
Unknown 9 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 34%
Medicine and Dentistry 10 19%
Agricultural and Biological Sciences 8 15%
Social Sciences 3 6%
Nursing and Health Professions 1 2%
Other 4 8%
Unknown 9 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2015.
All research outputs
of 6,297,749 outputs
Outputs from Cell Regeneration
of 34 outputs
Outputs of similar age
of 201,725 outputs
Outputs of similar age from Cell Regeneration
of 3 outputs
Altmetric has tracked 6,297,749 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 34 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one scored the same or higher as 6 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,725 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.