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Survival and local control rates of triple-negative breast cancer patients treated with boost-IOERT during breast-conserving surgery

Overview of attention for article published in Strahlentherapie und Onkologie, September 2015
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Title
Survival and local control rates of triple-negative breast cancer patients treated with boost-IOERT during breast-conserving surgery
Published in
Strahlentherapie und Onkologie, September 2015
DOI 10.1007/s00066-015-0895-2
Pubmed ID
Authors

Gerd Fastner, Cornelia Hauser-Kronberger, Angelika Moder, Roland Reitsamer, Franz Zehentmayr, Peter Kopp, Christoph Fussl, Thorsten Fischer, Heinrich Deutschmann, Felix Sedlmayer

Abstract

The purpose of this work was to retrospectively evaluate survival and local control rates of triple-negative breast cancer subtypes classified as five marker negative (5NP) and core basal (CB), respectively, after breast-conserving surgery and intraoperative boost radiotherapy with electrons (IOERT) followed by whole breast irradiation. A total of 71 patients with triple-negative breast cancer were enrolled, who were treated with lumpectomy, axillary lymph node dissection, and IOERT with 9.6 Gy (median Dmax) followed by normofractionated whole breast irradiation to median total doses of 54 Gy. Chemotherapy was applied in a neoadjuvant (12 %), adjuvant (75 %), or combinational setting (7 %). After a median follow-up of 97 months (range 4-170 months), 5 in-breast recurrences were detected (7.0 %). For all patients, 8-year actuarial rates for local control, metastases-free survival, disease-specific survival, and overall survival amounted to 89, 75, 80, and 69 %, respectively. All local recurrences occurred in grade 3 (G3) tumors irrespective of their specific immunohistochemical phenotype; thus, the local control rate for grades 1/2 (G1/2) was 100 % for both 5NP and CB, while for G3 it was 88 % for 5NP and 90 % for CB (p = 0.65 and 0.82, respectively, n.s.). For disease-specific survival, only the difference of the best-prognosis group 5-NP/G3 vs. the worst-prognosis cohort CB/G1/2 was statistically significant: 90 % vs. 54 % (p = 0.03). Boost-IOERT provides acceptable long-term in-breast control in triple negative breast cancer. The best subgroup in terms of disease-specific survival was represented by 5NP in combination with tumor grading G3.

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Unknown 15 100%
Readers by discipline Count As %
Unknown 15 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2015.
All research outputs
#10,837,406
of 12,225,678 outputs
Outputs from Strahlentherapie und Onkologie
#241
of 319 outputs
Outputs of similar age
#203,186
of 247,012 outputs
Outputs of similar age from Strahlentherapie und Onkologie
#8
of 15 outputs
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.