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De novo vitamin D supplement use post-diagnosis is associated with breast cancer survival

Overview of attention for article published in Breast Cancer Research and Treatment, July 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

twitter
9 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
23 Mendeley
citeulike
1 CiteULike
Title
De novo vitamin D supplement use post-diagnosis is associated with breast cancer survival
Published in
Breast Cancer Research and Treatment, July 2018
DOI 10.1007/s10549-018-4896-6
Pubmed ID
Authors

J. M. Madden, L. Murphy, L. Zgaga, K. Bennett

Abstract

Experimental laboratory data have indicated a protective effect of vitamin D on breast cancer progression, while epidemiological evidence is growing. Using pharmacy claims data, this study investigates the association between vitamin D supplement use initiated after a breast cancer diagnosis and associated mortality. Women aged 50-80 years with a record of invasive breast cancer were identified on the National Cancer Registry Ireland database (n = 5417). Initiation of de novo vitamin D post-diagnosis was identified from linked national prescription data (n = 2581, 49%). Multivariate Cox proportional hazards models were used to estimate adjusted HRs (95% CIs) for breast cancer-specific mortality. There was a 20% reduction in breast cancer-specific mortality in de novo vitamin D users (modelled as a time-varying variable) compared to non-users (HR 0.80; 95% CI 0.64-0.99, p = 0.048) and the reduction was greater at 49% (HR 0.51; 95% CI 0.34-0.74, p < 0.001), if vitamin D was initiated soon after the breast cancer diagnosis (within 6 months). In this large national breast cancer cohort, de novo vitamin D use post-diagnosis was found to be associated with a reduction in breast cancer-specific mortality. Vitamin D, therefore, has the potential as a non-toxic and inexpensive agent to improve survival in breast cancer patients. Findings support the need for RCTs exploring the effect of vitamin D supplementation on breast cancer survival.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 22%
Student > Bachelor 4 17%
Lecturer 3 13%
Unspecified 3 13%
Other 2 9%
Other 6 26%
Readers by discipline Count As %
Medicine and Dentistry 7 30%
Unspecified 3 13%
Biochemistry, Genetics and Molecular Biology 3 13%
Immunology and Microbiology 2 9%
Agricultural and Biological Sciences 2 9%
Other 6 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2019.
All research outputs
#3,037,808
of 13,406,972 outputs
Outputs from Breast Cancer Research and Treatment
#728
of 3,270 outputs
Outputs of similar age
#77,748
of 268,399 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#13
of 64 outputs
Altmetric has tracked 13,406,972 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,270 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,399 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.