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Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women

Overview of attention for article published in European Journal of Nutrition, July 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

blogs
1 blog
twitter
4 tweeters
facebook
1 Facebook page

Citations

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9 Dimensions

Readers on

mendeley
45 Mendeley
Title
Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women
Published in
European Journal of Nutrition, July 2018
DOI 10.1007/s00394-018-1784-0
Pubmed ID
Authors

S. Mörkl, S. Lackner, A. Meinitzer, H. Mangge, M. Lehofer, B. Halwachs, G. Gorkiewicz, K. Kashofer, A. Painold, A. K. Holl, S. A. Bengesser, W. Müller, P. Holzer, S. J. Holasek

Abstract

Increased gut permeability causes the trespass of antigens into the blood stream which leads to inflammation. Gut permeability reflected by serum zonulin and diversity of the gut microbiome were investigated in this cross-sectional study involving female study participants with different activity and BMI levels. 102 women were included (BMI range 13.24-46.89 kg m-2): Anorexia nervosa patients (n = 17), athletes (n = 20), normal weight (n = 25), overweight (n = 21) and obese women (n = 19). DNA was extracted from stool samples and subjected to 16S rRNA gene analysis (V1-V2). Quantitative Insights Into Microbial Ecology (QIIME) was used to analyze data. Zonulin was measured with ELISA. Nutrient intake was assessed by repeated 24-h dietary recalls. We used the median of serum zonulin concentration to divide our participants into a "high-zonulin" (> 53.64 ng/ml) and "low-zonulin" (< 53.64 ng/ml) group. The alpha-diversity (Shannon Index, Simpson Index, equitability) and beta-diversity (unweighted and weighted UniFrac distances) of the gut microbiome were not significantly different between the groups. Zonulin concentrations correlated significantly with total calorie-, protein-, carbohydrate-, sodium- and vitamin B12 intake. Linear discriminant analysis effect size (LEfSe) identified Ruminococcaceae (LDA = 4.163, p = 0.003) and Faecalibacterium (LDA = 4.151, p = 0.0002) as significantly more abundant in the low zonulin group. Butyrate-producing gut bacteria such as Faecalibacteria could decrease gut permeability and lower inflammation. The diversity of the gut microbiota in women does not seem to be correlated with the serum zonulin concentration. Further interventional studies are needed to investigate gut mucosal permeability and the gut microbiome in the context of dietary factors.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 8 18%
Student > Ph. D. Student 7 16%
Student > Master 6 13%
Researcher 6 13%
Student > Bachelor 6 13%
Other 12 27%
Readers by discipline Count As %
Unspecified 10 22%
Biochemistry, Genetics and Molecular Biology 9 20%
Medicine and Dentistry 8 18%
Agricultural and Biological Sciences 6 13%
Nursing and Health Professions 3 7%
Other 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2019.
All research outputs
#1,466,409
of 12,826,501 outputs
Outputs from European Journal of Nutrition
#338
of 1,391 outputs
Outputs of similar age
#51,610
of 268,083 outputs
Outputs of similar age from European Journal of Nutrition
#12
of 73 outputs
Altmetric has tracked 12,826,501 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,391 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.