| Title |
Altered Dynamics of the fMRI Response to Faces in Individuals with Autism
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, September 2015
|
| DOI | 10.1007/s10803-015-2565-8 |
| Pubmed ID | |
| Authors |
Natalia M. Kleinhans, Todd Richards, Jessica Greenson, Geraldine Dawson, Elizabeth Aylward |
| Abstract |
Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 127 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 23% |
| Student > Master | 19 | 15% |
| Student > Bachelor | 17 | 13% |
| Researcher | 14 | 11% |
| Student > Doctoral Student | 9 | 7% |
| Other | 10 | 8% |
| Unknown | 30 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 47 | 36% |
| Neuroscience | 15 | 12% |
| Medicine and Dentistry | 7 | 5% |
| Nursing and Health Professions | 6 | 5% |
| Social Sciences | 5 | 4% |
| Other | 15 | 12% |
| Unknown | 34 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2015.
All research outputs
#21,376,200
of 23,867,274 outputs
Outputs from Journal of Autism and Developmental Disorders
#4,711
of 5,240 outputs
Outputs of similar age
#230,644
of 270,246 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#84
of 87 outputs
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