Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells

NK細胞によるADCC(antibody-dependent cell-mediated cytotoxicity)には、CD16(Fc receptor)の発現が必要。一方、NK細胞に発現するADAM17(A disintegrin and metalloproteinase-17)はCD16を切断する。ADAM17活性の中和抗体は、ADCC時に産生されるIFN-γ産生能を亢進させることが分かった(MYG)。

本日(10月18日, 17時）J.C.は、Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cell, Cancer Immunology, Immunotherapy, 2018, Volume 67(9), pp1407-16 https://t.co/zhunwjA5dJです(MYG)。連絡遅れすいません

RT @NKcellBiology: Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound t…

Maybe it could also help in Malaria? https://t.co/UQ6OXeLwTy https://t.co/yQJhS3uIay

Targeting ADAM17 by a mab enhances Ifng production by NK cells. Work by Walcheck lab. I was obsessed with this pathway during my post doc in Miller lab at umn. PMID: 23487023 https://t.co/SKAPjee797

Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells. by Mishra HK, Pore N, Michelotti EF, Walcheck B https://t.co/G85F1L3YXv

Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells. https://t.co/qhTDOpol7q