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In vitro or not in vitro: a short journey through a long history

Overview of attention for article published in Environmental Sciences Europe, June 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

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4 tweeters

Citations

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7 Dimensions

Readers on

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40 Mendeley
Title
In vitro or not in vitro: a short journey through a long history
Published in
Environmental Sciences Europe, June 2018
DOI 10.1186/s12302-018-0151-3
Pubmed ID
Authors

Kristina Rehberger, Christian Kropf, Helmut Segner

Abstract

The aim of ecotoxicology is to study toxic effects on constituents of ecosystems, with the protection goal being populations and communities rather than individual organisms. In this ecosystem perspective, the use of in vitro methodologies measuring cellular and subcellular endpoints at a first glance appears to be odd. Nevertheless, more recently in vitro approaches gained momentum in ecotoxicology. In this article, we will discuss important application domains of in vitro methods in ecotoxicology. One area is the use of in vitro assays to replace, reduce, and refine (3R) in vivo tests. Research in this field has focused mainly on the use of in vitro cytotoxicity assays with fish cells as non-animal alternative to the in vivo lethality test with fish and on in vitro biotransformation assays as part of an alternative testing strategy for bioaccumulation testing with fish. Lessons learned from this research include the importance of a critical evaluation of the sensitivity, specificity and exposure conditions of in vitro assays, as well as the availability of appropriate in vitro-in vivo extrapolation models. In addition to this classical 3R application, other application domains of in vitro assays in ecotoxicology include the screening and prioritization of chemical hazards, the categorization of chemicals according to their modes of action and the provision of mechanistic information for the pathway-based prediction of adverse outcomes. The applications discussed in this essay may highlight the potential of in vitro technologies to enhance the environmental hazard assessment of single chemicals and complex mixtures at a reduced need of animal testing.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 28%
Student > Master 10 25%
Professor 4 10%
Other 3 8%
Researcher 3 8%
Other 9 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 28%
Environmental Science 10 25%
Unspecified 8 20%
Biochemistry, Genetics and Molecular Biology 7 18%
Chemical Engineering 1 3%
Other 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2018.
All research outputs
#6,886,827
of 13,644,952 outputs
Outputs from Environmental Sciences Europe
#92
of 222 outputs
Outputs of similar age
#107,179
of 269,000 outputs
Outputs of similar age from Environmental Sciences Europe
#1
of 1 outputs
Altmetric has tracked 13,644,952 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 222 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.8. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,000 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them