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Citrullination in the periodontium—a possible link between periodontitis and rheumatoid arthritis

Overview of attention for article published in Clinical Oral Investigations, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

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5 tweeters

Citations

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29 Dimensions

Readers on

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36 Mendeley
Title
Citrullination in the periodontium—a possible link between periodontitis and rheumatoid arthritis
Published in
Clinical Oral Investigations, August 2015
DOI 10.1007/s00784-015-1556-7
Pubmed ID
Authors

Oliver Laugisch, Alicia Wong, Aneta Sroka, Tomasz Kantyka, Joanna Koziel, Klaus Neuhaus, Anton Sculean, Patrick J. Venables, Jan Potempa, Burkhard Möller, Sigrun Eick

Abstract

The aim of the present study was to assess human and bacterial peptidylarginine deiminase (PAD) activity in the gingival crevicular fluid (GCF) in the context of serum levels of antibodies against citrullinated epitopes in rheumatoid arthritis and periodontitis. Human PAD and Porphyromonas gingivalis-derived enzyme (PPAD) activities were measured in the GCF of 52 rheumatoid arthritis (RA) patients (48 with periodontitis and 4 without) and 44 non-RA controls (28 with periodontitis and 16 without). Serum antibodies against citrullinated epitopes were measured by ELISA. Bacteria being associated with periodontitis were determined by nucleic-acid-based methods. Citrullination was present in 26 (50 %) RA patients and 23 (48 %) controls. PAD and PPAD activities were detected in 36 (69 %) and 30 (58 %) RA patients, respectively, and in 30 (68 %) and 21 (50 %) controls, respectively. PPAD activity was higher in RA and non-RA patients with periodontitis than in those without (p = 0.038; p = 0.004), and was detected in 35 of 59 P. gingivalis-positive samples, and in 16 of 37 P. gingivalis-negative samples in association with high antibody levels against that species. PAD and PPAD activities within the periodontium are elevated in RA and non-RA patients with periodontitis. PPAD secreted by P. gingivalis residing in epithelial cells may exert its citrullinating activity in distant regions of the periodontium or even distant tissues. In periodontitis, the citrullination of proteins/peptides by human and bacterial peptidylarginine deiminases may generate antibodies after breaching immunotolerance in susceptible individuals.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Researcher 6 17%
Student > Bachelor 6 17%
Unspecified 5 14%
Student > Postgraduate 3 8%
Other 9 25%
Readers by discipline Count As %
Medicine and Dentistry 14 39%
Agricultural and Biological Sciences 7 19%
Unspecified 6 17%
Biochemistry, Genetics and Molecular Biology 3 8%
Immunology and Microbiology 3 8%
Other 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2016.
All research outputs
#6,469,194
of 12,224,495 outputs
Outputs from Clinical Oral Investigations
#202
of 625 outputs
Outputs of similar age
#89,807
of 238,906 outputs
Outputs of similar age from Clinical Oral Investigations
#6
of 28 outputs
Altmetric has tracked 12,224,495 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 625 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,906 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.