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The Endocannabinoid System and its Modulation by Phytocannabinoids

Overview of attention for article published in Neurotherapeutics, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

5 tweeters
8 Facebook pages
1 Google+ user


60 Dimensions

Readers on

187 Mendeley
The Endocannabinoid System and its Modulation by Phytocannabinoids
Published in
Neurotherapeutics, August 2015
DOI 10.1007/s13311-015-0374-6
Pubmed ID

Vincenzo Di Marzo, Fabiana Piscitelli


The endocannabinoid system is currently defined as the ensemble of the two 7-transmembrane-domain and G protein-coupled receptors for Δ(9)-tetrahydrocannabinol (but not for most other plant cannabinoids or phytocannabinoids)-cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R); their two most studied endogenous ligands, the "endocannabinoids" N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG); and the enzymes responsible for endocannabinoid metabolism. However, anandamide and 2-AG, and also the phytocannabinoids, have more molecular targets than just CB1R and CB2R. Furthermore, the endocannabinoids, like most other lipid mediators, have more than just one set of biosynthetic and degrading pathways and enzymes, which they often share with "endocannabinoid-like" mediators that may or may not interact with the same proteins as Δ(9)-tetrahydrocannabinol and other phytocannabinoids. In some cases, these degrading pathways and enzymes lead to molecules that are not inactive and instead interact with other receptors. Finally, some of the metabolic enzymes may also participate in the chemical modification of molecules that have very little to do with endocannabinoid and cannabinoid targets. Here, we review the whole world of ligands, receptors, and enzymes, a true "endocannabinoidome", discovered after the cloning of CB1R and CB2R and the identification of anandamide and 2-AG, and its interactions with phytocannabinoids.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Spain 1 <1%
Unknown 184 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 40 21%
Student > Master 34 18%
Student > Ph. D. Student 30 16%
Unspecified 26 14%
Researcher 22 12%
Other 35 19%
Readers by discipline Count As %
Unspecified 36 19%
Agricultural and Biological Sciences 31 17%
Biochemistry, Genetics and Molecular Biology 29 16%
Medicine and Dentistry 23 12%
Neuroscience 19 10%
Other 49 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2017.
All research outputs
of 13,041,733 outputs
Outputs from Neurotherapeutics
of 574 outputs
Outputs of similar age
of 234,406 outputs
Outputs of similar age from Neurotherapeutics
of 18 outputs
Altmetric has tracked 13,041,733 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 574 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,406 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.