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Hepato- and nephrotoxicity in male albino rats exposed to malathion and spinosad in stored wheat grains

Overview of attention for article published in Acta Biologica Hungarica, June 2015
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Title
Hepato- and nephrotoxicity in male albino rats exposed to malathion and spinosad in stored wheat grains
Published in
Acta Biologica Hungarica, June 2015
DOI 10.1556/018.66.2015.2.1
Pubmed ID
Authors

Nour El-Hoda A. Zidan

Abstract

Adult male albino rats were fed on stored wheat grains (Triticum aestivum L.) treated with malathion and spinosad at both 8 and 16 ppm for 90 consecutive days to evaluate their hepatic and renal toxicity. The activity of serum acetylcholinesterase (AChE) was decreased in rats treated with the higher concentration of both tested pesticides. Biochemical parameters of liver functions [i.e., aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ACP) activity, as well as total protein, albumin, bilirubin and cholesterol levels] were severely affected especially at higher concentration. Malathion and spinosad elevated the activity of ALT, AST, ALP and ACP in rats treated with the higher concentration. Also, total and direct bilirubin levels increased in rats treated with the higher concentration of both pesticides. On the contrary, both pesticides decreased total protein and albumin levels in treated rats in a concentration-dependent manner. Furthermore, malathion was found to be hyperglycemic. Kidney function parameters (i.e., urea and creatinine levels) were increased in treated rats in a concentration-dependent manner. The above mentioned effects were supported by histopathological examination of liver and kidney tissues. The obtained results indicated also that malathion was able to cause a more pronounced hepato- and renal toxicity in rats than spinosad.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 17%
Student > Doctoral Student 1 17%
Student > Bachelor 1 17%
Professor 1 17%
Student > Master 1 17%
Other 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Agricultural and Biological Sciences 1 17%
Environmental Science 1 17%
Unknown 2 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2015.
All research outputs
#10,782,115
of 12,159,304 outputs
Outputs from Acta Biologica Hungarica
#68
of 127 outputs
Outputs of similar age
#195,571
of 237,166 outputs
Outputs of similar age from Acta Biologica Hungarica
#2
of 7 outputs
Altmetric has tracked 12,159,304 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 127 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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