Title |
Dancing cheek to cheek: Cryptococcus neoformans and phagocytes
|
---|---|
Published in |
SpringerPlus, August 2015
|
DOI | 10.1186/s40064-015-1192-3 |
Pubmed ID | |
Authors |
Mingshun Zhang, Donglei Sun, Meiqing Shi |
Abstract |
Meningoencephalitis caused by Cryptococcus neoformans (Cn) has become one of the leading causes of mortality in AIDS patients. Understanding the interactions between Cn and phagocytes is fundamental in exploring the pathogenicity of cryptococcal meningoencephalitis. Cn may be extracellular or contained in the monocytes, macrophages, neutrophils, dendritic cells and even endothelial cells. The internalized Cn may proliferate inside the host cells, or cause the lysis of host cells, or leave the host cells via non-lytic exocytosis, or even hijack the host cells (Trojan horse) for the brain dissemination, which are regulated by microbe factors and also immune molecules. Coexistence of protective and deleterious roles of phagocytes in the progression of cryptococcosis warrant further investigation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 19% |
Student > Bachelor | 7 | 19% |
Student > Ph. D. Student | 6 | 17% |
Student > Doctoral Student | 3 | 8% |
Researcher | 3 | 8% |
Other | 7 | 19% |
Unknown | 3 | 8% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 13 | 36% |
Biochemistry, Genetics and Molecular Biology | 8 | 22% |
Immunology and Microbiology | 5 | 14% |
Medicine and Dentistry | 2 | 6% |
Computer Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 6 | 17% |